{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:17:24Z","timestamp":1790720244120,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1064704"],"award-info":[{"award-number":["1064704"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>It is now necessary to investigate whether recovery in psychosis is possible without the use of antipsychotic medication. This study will determine (1) whether a first\u2010episode psychosis (FEP) group receiving intensive psychosocial interventions alone can achieve symptomatic remission and functional recovery; (2) whether prolonging the duration of untreated psychosis (DUP) in a sub\u2010group according to randomisation will be associated with a poorer outcome and thereby establish whether the relationship between DUP and outcome is causative; and (3) whether neurobiological changes observed in FEP are associated with the psychotic disorder or antipsychotic medication. Baseline characteristics of participants will be presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a triple\u2010blind randomized placebo\u2010controlled non\u2010inferiority trial. The primary outcome is the level of functioning measured by the Social and Occupational Functioning Assessment Scale at 6\u2009months. This study is being conducted at the Early Psychosis Prevention and Intervention Centre, Melbourne and includes young people aged 15 to 24\u2009years with a DSM\u2010IV psychotic disorder, a DUP less than 6\u2009months and not high risk for suicide or harm to others. Strict discontinuation criteria are being applied. Participants are also undergoing three 3\u2010Tesla\u2010MRI scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety participants have been recruited and baseline characteristics are presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Staged treatment and acceptability guidelines in early psychosis will determine whether antipsychotic medications are indicated in all young people with a FEP and whether antipsychotic medication can be safely delayed. Furthermore, the relative contribution of psychotic illness and antipsychotic medication in terms of structural brain changes will also be elucidated. The findings will inform clinical practice guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12716","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T07:31:16Z","timestamp":1562052676000},"page":"953-960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Staged treatment and acceptability guidelines in early psychosis study (STAGES): A randomized placebo controlled trial of intensive psychosocial treatment plus or minus antipsychotic medication for first\u2010episode psychosis with low\u2010risk of self\u2010harm or aggression. Study protocol and baseline characteristics of participants"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-6952","authenticated-orcid":false,"given":"Brian","family":"O'Donoghue","sequence":"first","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Australia"},{"name":"Orygen Youth Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8305-8982","authenticated-orcid":false,"given":"Shona M.","family":"Francey","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Australia"},{"name":"Orygen Youth Health  Melbourne 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