{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:47:41Z","timestamp":1784598461227,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["566529"],"award-info":[{"award-number":["566529"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009128","name":"Research for Patient Benefit Programme","doi-asserted-by":"publisher","award":["PB\u2010PG\u20100609\u201016166"],"award-info":[{"award-number":["PB\u2010PG\u20100609\u201016166"]}],"id":[{"id":"10.13039\/501100009128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Clinical staging models offer a useful framework for understanding illness trajectories, where individuals are located on a continuum of illness progression from stage 0 (at\u2010risk but asymptomatic) to stage 4 (end\u2010stage disease). Importantly, clinical staging allows investigation of risk factors for illness progression with the potential to target trans\u2010diagnostic mechanisms at an early stage, especially in help\u2010seeking youth who often present with sub\u2010threshold syndromes. While depressive symptoms, rumination and sleep\u2010wake disturbances may worsen syndrome outcomes, the role of these related phenomena has yet to be examined as risk factors for trans\u2010diagnostic illness progression in at\u2010risk youth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a prospective follow\u2010up of 248 individuals aged 12 to 25 years presenting to <jats:italic>headspace<\/jats:italic> services with sub\u2010threshold syndromes (stage 1) classified under the clinical staging model to determine transition to threshold syndromes (stage 2). Factor analysis of depression, rumination and sleep\u2010wake patterns was used to identify key dimensions and any associations between factors and transition to stage 2 at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1 year, 9% of cases met criteria for stage 2 (n = 22). One of three identified factors, namely the factor reflecting the commonalities shared between rumination and sleep\u2010wake disturbance, significantly differentiated cases that transitioned to stage 2 vs those that did not demonstrate transition. Items loading onto this factor, labelled Anergia, included depression severity and aspects of rumination and sleep\u2010wake disturbance that were characterized as introceptive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Common dimensions between rumination and sleep\u2010wake disturbance present a detectable trans\u2010diagnostic marker of illness progression in youth, and may represent a target for early intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12757","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T19:12:25Z","timestamp":1543432345000},"page":"1214-1219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Can youth at high risk of illness progression be identified by measures of rumination and sleep\u2010wake 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D.","family":"McGorry","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Pantelis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Melbourne Neuropsychiatry Centre University of Melbourne and Melbourne Health  Carlton South Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1060-6068","authenticated-orcid":false,"given":"Lisa","family":"Phillips","sequence":"additional","affiliation":[{"name":"Melbourne School of Psychological Sciences University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Scott","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Institute The University of Sydney  Sydney New South Wales Australia"},{"name":"School of Medicine, Notre Dame University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison R.","family":"Yung","sequence":"additional","affiliation":[{"name":"Division of Psychology and Mental Health, Manchester Academic Health Science Centre University of Manchester  Manchester UK"},{"name":"Greater Manchester Mental Health NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Purcell","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne 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