{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:05:48Z","timestamp":1770984348931,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T00:00:00Z","timestamp":1549756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1128626"],"award-info":[{"award-number":["APP1128626"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Young people with bipolar disorder (BD) commonly experience reduced quality of life, persistent symptoms and impaired functional recovery despite often superior school performance. Compromised long\u2010term functioning can ensue. There is evidence that psychological therapies alongside pharmacology may be more efficacious earlier in the course of the disorder. Intervention in the early stages may thus reduce the burden and risk associated with BD and mitigate the impact of the disorder on normal developmental trajectories. To date, however, the availability of evidence\u2010based psychological therapies for young people with early BD is limited. Furthermore, there are no large\u2010scale randomized controlled trials (RCTs) of such interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study is a prospective, single\u2010blind, RCT examining the effectiveness of an adjunctive individualized and manualized psychological intervention, compared with treatment as usual within youth\u2010specific early intervention services. The REsearch into COgnitive and behavioural VERsatility (RECOVER) intervention is delivered over a 6\u2010month period. About 122 young people in the early stages of BD\u2010I (at least one manic episode in the previous 2 years, with no more than five lifetime treated\/untreated manic or hypomanic episodes) will be recruited. The assessments will occur at baseline, 3, 6 (primary endpoint, end of treatment), 9, 12, 15 and 18 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recruitment will commence in January 2019 and is anticipated to occur over a 3.5\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To date, there are no evidence\u2010based psychological therapies tailored to young people with early BD. We will test whether early psychological intervention in the course of BD can reduce the symptomatic, psychological, vocational and social impacts that are seen in entrenched disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12797","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T04:23:58Z","timestamp":1549859038000},"page":"1470-1479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Improving functional outcomes in early\u2010stage bipolar disorder: The protocol for the REsearch into COgnitive and behavioural VERsatility trial"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9386-8348","authenticated-orcid":false,"given":"Sue M.","family":"Cotton","sequence":"first","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-6946","authenticated-orcid":false,"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"IMPACT Strategic Research Centre, Deakin University, School of Medicine  Geelong Victoria Australia"},{"name":"The Department of Psychiatry and the Florey Institute for Neuroscience and Mental Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Jackson","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Murray","sequence":"additional","affiliation":[{"name":"Centre for Mental Health, Department of Psychological Sciences Swinburne University of Technology  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Filia","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Hasty","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-622X","authenticated-orcid":false,"given":"Andrew","family":"Chanen","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Orygen Youth Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Davey","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Orygen Youth Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barnaby","family":"Nelson","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Orygen Youth Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aswin","family":"Ratheesh","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Orygen Youth Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-1593","authenticated-orcid":false,"given":"Craig","family":"MacNeil","sequence":"additional","affiliation":[{"name":"Orygen, The National Centre of Excellence in Youth Mental Health  Melbourne Victoria Australia"},{"name":"Centre for Youth Mental Health The University of Melbourne  Melbourne Victoria Australia"},{"name":"Orygen Youth Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.10.009"},{"key":"e_1_2_7_3_1","unstructured":"American Psychiatric Association. (2013). The Personality Inventory for DSM\u20105 \u2013Brief Form (PID\u20105\u2010BF) \u2013Adult. Retrieved fromhttps:\/\/www.psychiatry.org\/File\u00a0Library\/Psychiatrists\/Practice\/DSM\/APA_DSM5_The\u2010Personality\u2010Inventory\u2010For\u2010DSM\u20105\u2010Brief\u2010Form\u2010Adult.pdf"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.1.3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12099"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.186833"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01328.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/8.3.470"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.04.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.09.009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.09.009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00315.x"},{"key":"e_1_2_7_13_1","volume-title":"Handbook of cognitive behavioral therapies","author":"Dobson K.","year":"2009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790260103013"},{"key":"e_1_2_7_15_1","volume-title":"Social inclusion in mental illness (PhD)","author":"Filia K. M.","year":"2015"},{"key":"e_1_2_7_16_1","volume-title":"Structured clinical interview for DSM\u20105\u00ae personality disorders (SCID\u20105\u2010PD)","author":"First M. B.","year":"2016"},{"key":"e_1_2_7_17_1","volume-title":"Structured clinical interview for DSM\u20105\u2014Research version (SCID\u20105 for DSM\u20105, research version; SCID\u20105\u2010RV)","author":"First M. B.","year":"2015"},{"key":"e_1_2_7_18_1","volume-title":"Treating bipolar disorder: A clinician's guide to interpersonal and social rhythm therapy","author":"Frank E.","year":"2005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2007.9.3\/efrank"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60512-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.3.310"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/clipsy.9.3.329"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa8201_13"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20668"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-0167.36.2.223"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12273"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpp.584"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.141259"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.166.5.654"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2018.191"},{"key":"e_1_2_7_32_1","volume-title":"Cognitive therapy for bipolar disorder: A Therapist's guide to concepts, methods and practice","author":"Lam D. H.","year":"1999"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/949248"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.060368"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2011.00336.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2011.00336.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511757389"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415617657"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1614.2006.01860.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12001"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00865.x"},{"issue":"1","key":"e_1_2_7_42_1","first-page":"e5","article-title":"Evidence\u2010based family interventions for adolescents and young adults with bipolar disorder","volume":"77","author":"Miklowitz D.","year":"2016","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-015-0057-z"},{"key":"e_1_2_7_44_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.eurpsy.2018.05.006","article-title":"Patient centric measures for a patient centric era: Agreement and convergent between ratings on the patient global impression of improvement (PGI\u2010I) scale and the clinical global impressions\u2013Improvement (CGI\u2010S) scale in bipolar and major depressive disorder","volume":"53","author":"Mohebbi M.","year":"2018","journal-title":"European Psychiatry"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.15.1987"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12655"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2017.01.002"},{"key":"e_1_2_7_49_1","volume-title":"Bipolar disorder: The assessment and management of bipolar disorder NICE clinical guidelines","author":"National Institute for Health and Care Excellence","year":"2014"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/15298860309027"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20182"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10111704"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.12.017"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-013-0036-x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-0179-3-5"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145713000953"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2011.10.001"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199606003-00015"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(97)00123-6"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12118"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10060tx3cc"},{"key":"e_1_2_7_63_1","unstructured":"Therapeutic Good Administration. (2018). Australian clinical trials handbook: Guidance on conducting clincial trials in Australia using \u201cunapproved\u201d therapeutic goods. Retrieved fromhttps:\/\/www.tga.gov.au\/sites\/default\/files\/australian-clinical-trial-handbook-01.pdf"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00130-9"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00156-X"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420529908998724"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900028728"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"}],"container-title":["Early Intervention in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feip.12797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.12797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eip.12797","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.12797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T02:56:56Z","timestamp":1694228216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.12797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,10]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/eip.12797"],"URL":"https:\/\/doi.org\/10.1111\/eip.12797","archive":["Portico"],"relation":{},"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,10]]},"assertion":[{"value":"2018-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}