{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:43:26Z","timestamp":1780368206449,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Janssen Scientific Affairs, LLC"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This exploratory post hoc analysis of a randomized, double\u2010blind (DB), multicentre, non\u2010inferiority study (NCT01515423) evaluated the effects of the long\u2010acting injectable antipsychotic therapies once\u2010monthly paliperidone palmitate (PP1M) and once\u2010every\u20103\u2010months paliperidone palmitate (PP3M) on symptom severity and functional remission in patients with schizophrenia with differing durations of illness (\u22645, 6\u201010 and &gt;10\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Endpoints included Personal and Social Performance (PSP) scale and Positive and Negative Syndrome Scale (PANSS) total scores during the DB phase (DB baseline and DB endpoint) and the proportion of patients meeting PSP or PANSS remission criteria at any time during the open\u2010label (OL) or DB phases that were maintained for \u22653, \u22656, \u22659 or \u226512\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both the OL and DB phases, significant improvements in PSP scale and PANSS scores were observed from baseline in all duration\u2010of\u2010illness groups, with significantly greater improvements observed in the \u22645\u2010year and 6\u201010\u2010year groups compared with the &gt;10\u2010year group. The proportion of patients who maintained PSP or PANSS remission criteria for \u22653, \u22656, \u22659 and \u226512\u2009months was higher in the \u22645\u2010year and 6\u201010\u2010year groups than in the &gt;10\u2010year group. Safety profiles were similar across duration\u2010of\u2010illness groups in the DB phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Symptomatic and functional improvements were observed with PP1M\/PP3M in patients with differing durations of schizophrenia, but the magnitude of the effects was greater in those with early illness vs chronic illness. These findings advocate implementation of PP1M and PP3M in all stages of schizophrenia, including early illness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12868","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T07:24:45Z","timestamp":1568359485000},"page":"428-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of paliperidone palmitate long\u2010acting injectable antipsychotic therapy as an early treatment option in patients with schizophrenia"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-6344","authenticated-orcid":false,"given":"Brianne","family":"Brown","sequence":"first","affiliation":[{"name":"Janssen Scientific Affairs LLC  Titusville New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Turkoz","sequence":"additional","affiliation":[{"name":"Janssen Research and Development LLC  Titusville New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branislav","family":"Mancevski","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs LLC  Titusville New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maju","family":"Mathews","sequence":"additional","affiliation":[{"name":"Janssen Research and Development LLC  Titusville New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2008.00495.x"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Treatment effect with paliperidone palmitate compared with oral antipsychotics in patients with recent\u2010onset versus more chronic schizophrenia and a history of criminal justice system involvement","volume":"12","author":"Alphs L.","year":"2015","journal-title":"Early Intervention in Psychiatry"},{"issue":"6","key":"e_1_2_7_4_1","first-page":"336","article-title":"Rethinking the role of long\u2010acting atypical antipsychotics in the community setting","volume":"27","author":"Altamura A. 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