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This study examines whether subthreshold conditions are comorbid and whether there is heterotypic continuity also between STS and FTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were extracted from the Brisbane \u201c19Up\u201d cohort study of twins and siblings (N = 1838; 56% female) on individuals who (i) completed self\u2010report ratings of depression\u2010like (DLE), hypomanic\u2010like (HMLE) and psychotic\u2010like experiences (PLE) and (ii) were assessed for mood and psychotic FTS using the Composite International Diagnostic Interview (CIDI). Associations between STS and FTS were estimated using adjusted prevalence ratios (APR) and 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>STS are prevalent, with 22% reporting DLE, 14% HMLE and 5% PLE; 7% reported &gt;1 STS, with PLE most likely to demonstrate comorbidity. Individuals with DLE were likely to meet CIDI criteria for depression (APR: 3.71, 95% CI: 2.83, 4.89), hypo\/mania (APR: 3.62, 95% CI: 2.21, 5.94) and psychotic disorders (APR: 1.74, 95% CI 1.08, 2.83). Individuals with HMLE were likely to meet CIDI criteria for depression (APR: 2.29, 95% CI: 1.58, 3.31) and hypo\/mania (APR: 2.51, 95% CI: 1.29, 4.91); those with PLE were likely to meet criteria for hypo\/mania (APR: 5.8, 95% CI: 1.90, 17.70) and psychotic disorders (APR: 17.27, 95% CI: 7.54, 39.65).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings suggest that STS are common among young adults and show heterotypic as well as homotypic continuity with FTS and support the need for more trans\u2010diagnostic research on the evolution of major mental disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.12942","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T05:25:43Z","timestamp":1581571543000},"page":"306-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence of self\u2010reported subthreshold phenotypes of major mental disorders and their association with functional impairment, treatment and full\u2010threshold syndromes in a community\u2010residing cohort of young adults"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7203-8601","authenticated-orcid":false,"given":"Jan","family":"Scott","sequence":"first","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney Australia"},{"name":"Institute of Neuroscience Newcastle University  Newcastle United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Martin","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Institute of Medical Research  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Parker","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Institute of Medical Research  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Couvy\u2010Duchesne","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Institute of Medical Research  Brisbane Australia"},{"name":"Institute of Molecular Bioscience The University of Queensland  Brisbane Australia"},{"name":"Brain and Spine Institute (ICM)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Medland","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Institute of Medical Research  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Hickie","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"Clinical and functional characteristics of youth at clinical high\u2010risk for psychosis who do not transition to psychosis","volume":"4","author":"Addington J.","year":"2018","journal-title":"Psychological Medicine"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12205"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.5694\/j.1326-5377.2010.tb03688.x","article-title":"The Internet as a setting for mental health service utilisation by young people","volume":"192","author":"Burns J.","year":"2010","journal-title":"Medical Journal of Australia"},{"key":"e_1_2_9_5_1","volume-title":"Protocol for the brain and mind centre optymise cohort: Tracking multi\u2010dimensional outcomes in young people presenting for mental health care","author":"Carpenter J","year":"2019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2011.02446.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.8.837"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-018959"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201700046"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114593"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2012.00366.x"},{"key":"e_1_2_9_13_1","article-title":"Applying a clinical staging framework in young people who present with admixtures of anxious, depressive or psychotic symptoms","author":"Hickie I. 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