{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:34:29Z","timestamp":1791221669882,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"publisher","award":["07TGF\u20101102"],"award-info":[{"award-number":["07TGF\u20101102"]}],"id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurocognitive impairments are core early features of psychosis and are observed in those at ultra\u2010high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Erythrocyte levels of total omega\u20103\u2010and omega\u20106 PUFAs the omega\u20103\/omega\u20106 ratio, were measured in 265 UHR individuals. Six domains of neurocognition as well a Composite Score, were assessed using the Brief Assessment of Cognition in Schizophrenia. Pearson's correlations were used to assess the relationship between PUFAs and neurocognition. All analyses were controlled for tobacco smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Verbal Fluency correlated positively with eicosapentaenoic acid (<jats:italic>P<\/jats:italic>\u2009=\u2009.024) and alpha\u2010linolenic acid (<jats:italic>P<\/jats:italic>\u2009=\u2009.01), and negatively with docosahexanoic acid (<jats:italic>P<\/jats:italic>\u2009=\u2009.007) and Working Memory positively correlated with omega\u20103\/omega\u20106 ratio (<jats:italic>P<\/jats:italic>\u2009=\u2009.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current results provide support for a relationship between Verbal Fluency and omega\u20103 PUFAs in UHR. Further investigation is required to elucidate whether these biomarkers are useful as risk markers or in understanding the biological underpinning of neurocognitive impairment in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.13025","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T07:30:25Z","timestamp":1600414225000},"page":"874-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Omega\u20103 fatty acids and neurocognitive ability in young people at ultra\u2010high risk for psychosis"],"prefix":"10.1111","volume":"15","author":[{"given":"Alison","family":"McLaverty","sequence":"first","affiliation":[{"name":"Melbourne School of Psychological Sciences The University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A.","family":"Allott","sequence":"additional","affiliation":[{"name":"Orygen The National Centre of Excellence in Youth Mental Health  Parkville Australia"},{"name":"The Centre for Youth Mental Health The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximus","family":"Berger","sequence":"additional","affiliation":[{"name":"Orygen The National Centre of Excellence in Youth Mental Health  Parkville Australia"},{"name":"The Centre for Youth Mental Health The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Hester","sequence":"additional","affiliation":[{"name":"Melbourne School of Psychological Sciences The University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"McGorry","sequence":"additional","affiliation":[{"name":"Orygen The National Centre of Excellence in Youth Mental Health  Parkville Australia"},{"name":"The Centre for Youth Mental Health The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnaby","family":"Nelson","sequence":"additional","affiliation":[{"name":"Orygen The National Centre of Excellence in Youth Mental Health  Parkville Australia"},{"name":"The Centre for Youth Mental Health The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Markulev","sequence":"additional","affiliation":[{"name":"Orygen The National Centre of Excellence in Youth Mental Health  Parkville Australia"},{"name":"The Centre for Youth Mental Health The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hok Pan","family":"Yuen","sequence":"additional","affiliation":[{"name":"Orygen The National Centre of Excellence in Youth Mental Health  Parkville Australia"},{"name":"The Centre for Youth Mental Health The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam R.","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Orygen The National Centre of Excellence in Youth Mental Health  Parkville Australia"},{"name":"Department of Child and Adolescent Psychiatry Medical University Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilufar","family":"Mossaheb","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Medical University Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Schl\u00f6gelhofer","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Medical University Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Smesny","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University Hospital Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian B.","family":"Hickie","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor Emanuel","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy University Hospital of Psychiatry Zurich, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y. 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