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Social impairment takes many forms including social withdrawal, relational aggression, physical aggression, and victimization. The aim of this study was to explore the links between social impairment and clinical symptoms in youth at high\u2010risk for BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample included 127 youths with elevations in mood symptoms (depression or hypomania) and at least one first and\/or second degree relative with BD. Measures of youths' current psychopathology (i.e., depressive and manic severity, suicidality, anxiety, and attention\u2010deficit\/hyperactivity disorder [ADHD]) were regressed onto youths' self\u2010reports of social impairment (i.e., social withdrawal, relational aggression, physical aggression, and victimization).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Depressive symptoms, suicidal ideation, and anxiety symptoms were related to social withdrawal. Suicidal ideation was also related to reactive aggression. ADHD symptoms related to reactive and proactive aggression as well as relational victimization. Manic symptoms were not associated with social impairment in this sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although cross\u2010sectional, study findings point to potential treatment targets related to social functioning. Specifically, social withdrawal should be a target for treatment of childhood depressive and anxiety symptoms. Treatments that focus on social skills and cognitive functioning deficits associated with BD may also have clinical utility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.13124","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T10:10:16Z","timestamp":1612951816000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Social impairment in relation to clinical symptoms in youth at high risk for bipolar disorder"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-120X","authenticated-orcid":false,"given":"Marc J.","family":"Weintraub","sequence":"first","affiliation":[{"name":"Semel Institute for Neuroscience and Human Behavior University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Keenan\u2010Miller","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Schneck","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcy","family":"Forgey Borlik","sequence":"additional","affiliation":[{"name":"Semel Institute for Neuroscience and Human Behavior University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Suddath","sequence":"additional","affiliation":[{"name":"Semel Institute for Neuroscience and Human Behavior University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Marvin","sequence":"additional","affiliation":[{"name":"Semel Institute for Neuroscience and Human Behavior University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manpreet K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiki D.","family":"Chang","sequence":"additional","affiliation":[{"name":"Private Practice  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Miklowitz","sequence":"additional","affiliation":[{"name":"Semel Institute for Neuroscience and Human Behavior University of California  Los Angeles California USA"},{"name":"Department of Psychology University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Exposure therapy for anxiety: Principles and practice","author":"Abramowitz J. 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