{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:53:55Z","timestamp":1793055235189,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000724","name":"Health Foundation","doi-asserted-by":"publisher","award":["GIFTS 7294\/CRM 1216"],"award-info":[{"award-number":["GIFTS 7294\/CRM 1216"]}],"id":[{"id":"10.13039\/501100000724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>First Episode Rapid Early Intervention for Eating Disorders (FREED) is a service model and care pathway for emerging adults aged 16 to 25\u2010years with a recent onset eating disorder (ED) of &lt;3\u2009years. A previous single\u2010site study suggests that FREED significantly improves clinical outcomes compared to treatment\u2010as\u2010usual (TAU). The present study (FREED\u2010Up) assessed the scalability of FREED. A multi\u2010centre quasi\u2010experimental pre\u2010post design was used, comparing patient outcomes before and after implementation of FREED in participating services.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      FREED patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009278) were consecutive, prospectively ascertained referrals to four specialist ED services in England, assessed at four time points over 12\u2009months on ED symptoms, mood, service utilization and cost. FREED patients were compared to a TAU cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009224) of similar patients, identified retrospectively from electronic patient records in participating services. All were emerging adults aged 16\u201325 experiencing a first episode ED of &lt;3\u2009years duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, FREED patients made significant and rapid clinical improvements over time. 53.2% of FREED patients with anorexia nervosa reached a healthy weight at the 12\u2010month timepoint, compared to only 17.9% of TAU patients (\n                      <jats:italic>X<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      [1,\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u2009107]\u00a0=\u00a010.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u2009.001). Significantly fewer FREED patients required intensive (i.e., in\u2010patient or day\u2010patient) treatment (6.6%) compared to TAU patients (12.4%) across the follow\u2010up period (\n                      <jats:italic>X<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      [1,\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u200940]\u00a0=\u00a04.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.037). This contributed to a trend in cost savings in FREED compared to TAU (\u2212\u00a34472,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.06, CI \u2212\u00a39168, \u00a3233).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>FREED is robust and scalable and is associated with substantial improvements in clinical outcomes, reduction in inpatient or day\u2010patient admissions, and cost\u2010savings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eip.13139","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T19:53:37Z","timestamp":1617047617000},"page":"97-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["The First Episode Rapid Early Intervention for Eating Disorders \u2010 Upscaled study: Clinical outcomes"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4979-4847","authenticated-orcid":false,"given":"Amelia","family":"Austin","sequence":"first","affiliation":[{"name":"Eating Disorders Section, Department of Psychological Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Flynn","sequence":"additional","affiliation":[{"name":"Eating Disorders Section, Department of Psychological Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Shearer","sequence":"additional","affiliation":[{"name":"Department of Health Services and Population Research King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Long","sequence":"additional","affiliation":[{"name":"Kent Surrey Sussex Academic Health Science Network  Crawley 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