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While previous neuroimaging studies of MD have reported both pre\u2010treatment structural and functional alterations, the effects of MBCT\u2010C on brain morphological network organisation has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated brain morphological network organisation in 10 mood\u2010dysregulated youth with familial risk for bipolar disorder and 15 matched healthy comparison youth (HC). Effects of 12\u2009weeks of MBCT\u2010C were examined in the mood\u2010dysregulated youth. Topological properties of brain networks used for analyses were constructed based on morphological similarities in regional grey matter using a graph\u2010theory approach using MRI data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, compared with the HC group, the mood\u2010dysregulated group exhibited increased global efficiency (<jats:italic>E<\/jats:italic><jats:sub>glob<\/jats:sub>), decreased path length (<jats:italic>L<\/jats:italic><jats:sub>p<\/jats:sub>), and abnormal nodal properties, mainly in the limbic system. Right temporal pole alterations at baseline predicted change in Child and Adolescent Mindfulness Measure scores after treatment. The mood\u2010dysregulated group showed significant decreases in both the <jats:italic>E<\/jats:italic><jats:sub>glob<\/jats:sub> and <jats:italic>L<\/jats:italic><jats:sub>p<\/jats:sub> metrics after MBCT\u2010C, suggesting an improved capacity for optimal information processing. Changes in <jats:italic>L<\/jats:italic><jats:sub>p<\/jats:sub> were correlated with changes in Emotion Regulation Checklist scores. Our results show significant topological alterations in the mood\u2010dysregulated group as compared to controls at baseline. After MBCT\u2010C, disrupted topological properties in the mood\u2010dysregulated group were significantly reduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MBCT\u2010C may facilitate clinically meaningful changes in the brain structural network in mood\u2010dysregulated individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.13245","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T23:13:45Z","timestamp":1637622825000},"page":"1011-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A preliminary study of the effects of mindfulness\u2010based cognitive therapy on structural brain networks in mood\u2010dysregulated youth with a familial risk for bipolar disorder"],"prefix":"10.1111","volume":"16","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC), Departments of Radiology West 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