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Correlations between deficits in FEE skills and visual\u2010spatial abilities in people with 22q11.2DS warrant investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample consisted of 37 patients with 22q11.2DS (DEL), 19 with 22q11.2DS and psychosis (DEL\u2010SCZ), 23 with idiopathic SCZ, and 48 healthy controls. We assessed FEE through <jats:italic>The Ekman 60 Faces<\/jats:italic> test (EK\u2010F60), visual\u2010spatial skills with <jats:italic>Raven's Standard Progressive Matrices<\/jats:italic>, and symptom severity with the <jats:italic>positive And negative syndrome scale<\/jats:italic>. Statistics were conducted through multivariate analysis of variance and correlation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with 22q11.2DS performed worse that the other groups in recognizing <jats:italic>Surprise<\/jats:italic>, <jats:italic>Disgust<\/jats:italic>, <jats:italic>Rage<\/jats:italic>, <jats:italic>Fear<\/jats:italic>, and Neutral expressions on the EK\u2010F60. Recognition of <jats:italic>Surprise<\/jats:italic> and <jats:italic>Disgust<\/jats:italic> correlated positively with visual\u2010spatial abilities in patients with 22q11.2DS; negative and cognitive symptoms correlated negatively with recognition of <jats:italic>Sadness<\/jats:italic>, <jats:italic>Surprise<\/jats:italic>, and <jats:italic>Disgust<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with 22q11.2DS show impairments of both peripheral and central steps of the emotional recognition process, leading to SC deficits. The latter are present regardless of the presence of a full\u2010blown psychosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.13295","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T01:38:27Z","timestamp":1648517907000},"page":"76-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recognition of facial emotion expressions and perceptual processes in 22q11.2 deletion syndrome"],"prefix":"10.1111","volume":"17","author":[{"given":"Antonino","family":"Buzzanca","sequence":"first","affiliation":[{"name":"Department of Human Neurosciences, Faculty of Medicine and Dentistry Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-6475","authenticated-orcid":false,"given":"Tommaso","family":"Accinni","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences, Faculty of Medicine 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