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Clinical presentations of these disorders are often indistinguishable, hindering assessment and treatment. Despite substantial research identifying cognitive deficits, eye movement abnormalities and speech impairment associated with primary psychotic disorders, these neuropsychological features have not been explored as targets for diagnostic differentiation in early psychosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen participants with cannabis\u2010induced psychosis (M<jats:sub>age<\/jats:sub>\u00a0=\u00a021.9, <jats:italic>SD<\/jats:italic><jats:sub>age<\/jats:sub>\u00a0=\u00a04.25, 14 male) and 19 participants with primary psychosis (M<jats:sub>age<\/jats:sub>\u00a0=\u00a029.2, <jats:italic>SD<\/jats:italic><jats:sub>age<\/jats:sub>\u00a0=\u00a07.65, 17 male) were recruited from early intervention programs. Diagnoses were ascertained by primary treatment teams after a minimum of 6\u00a0months in the program. Participants completed tasks assessing cognitive performance, saccadic eye movements and speech. Clinical symptoms, trauma, substance use, premorbid functioning and illness insight were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relative to individuals with primary psychosis, individuals with cannabis\u2010induced psychosis demonstrated significantly better performance on the pro\u2010saccade task, faster RT on pro\u2010 and anti\u2010saccade tasks, better premorbid adjustment, and a higher degree of insight into their illness. There were no significant differences between groups on psychiatric symptoms, premorbid intellectual functioning, or problems related to cannabis use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In early stages of illness, reliance on traditional diagnostic tools or clinical interviews may be insufficient to distinguish between cannabis\u2010induced and primary psychosis. Future research should continue to explore neuropsychological differences between these diagnoses to improve diagnostic accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.13348","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:23:06Z","timestamp":1660123386000},"page":"564-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A neuropsychological approach to differentiating <scp>cannabis\u2010induced<\/scp> and primary psychotic disorders"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-7075","authenticated-orcid":false,"given":"Stephanie M.","family":"Woolridge","sequence":"first","affiliation":[{"name":"Department of Psychology Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Wood\u2010Ross","sequence":"additional","affiliation":[{"name":"Department of Psychology Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Voleti","sequence":"additional","affiliation":[{"name":"School of Electrical, Computer, &amp; Energy Engineering Arizona State University  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Psychology Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visar","family":"Berisha","sequence":"additional","affiliation":[{"name":"School of Electrical, Computer, &amp; Energy Engineering Arizona State University  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1983-8861","authenticated-orcid":false,"given":"Christopher R.","family":"Bowie","sequence":"additional","affiliation":[{"name":"Department of Psychology Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.02.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70359-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1979.01780120045006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700030324"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbi025"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000442"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0142716400000072"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(03)00189-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjschz.2015.30"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt085"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12029"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/nedt.2006.2.4.531"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.022"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.3.385"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.09.003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/8.3.470"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.2.137"},{"key":"e_1_2_9_20_1","unstructured":"Chapman J.(1964).On the early diagnosis of schizophrenia(Doctoral dissertation). 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