{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:17:41Z","timestamp":1790720261208,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiovascular and metabolic diseases are the leading contributors to the early mortality associated with psychotic disorders. To date, it has not been possible to disentangle the effect of medication and non\u2010medication factors on the physical health of people with a first episode of psychosis (FEP). This study aimed to isolate the effects of antipsychotic medication on anthropometric measurements, fasting glucose and lipids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study utilized data from a triple\u2010blind randomized placebo\u2010controlled trial comparing two groups of antipsychotic\u2010na\u00efve young people with a FEP who were randomized to receive a second\u2010generation antipsychotic medication (FEP\u2010medication group) or placebo (FEP\u2010placebo group) for 6\u2009months. Twenty\u2010seven control participants were also recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one participants commenced the trial; 69.1% completed at least 3\u2009months of the intervention and 33.3% completed the full 6\u2009months. The FEP\u2010placebo group gained a mean of 2.4\u2009kg (\u00b14.9) compared to 1.1\u00a0kg (\u00b14.9) in the control participants (<jats:italic>t<\/jats:italic>\u00a0=\u00a00.76, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.45). After controlling for multiple analyses, there was no difference in blood pressure, waist circumference or heart rate between the FEP\u2010placebo group and controls. After 6\u2009months, the FEP medication group had gained 4.1\u00a0kg (\u00b14.5), higher than those receiving placebo but not statistically significant (<jats:italic>t<\/jats:italic>\u00a0=\u00a00.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.44). There were no differences in fasting glucose or lipids between the FEP groups after 3\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While limited by small numbers and high attrition, these findings indicate that some of the metabolic complications observed in psychotic disorders could be attributable to factors other than medication. This emphasizes the need to deliver physical health interventions early in the course of FEP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.13353","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T06:05:09Z","timestamp":1664949909000},"page":"597-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Isolating the impact of antipsychotic medication on metabolic health: Secondary analysis of a randomized controlled trial of antipsychotic medication versus placebo in antipsychotic medication na\u00efve first\u2010episode psychosis (the <scp>STAGES<\/scp> study)"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6240-6952","authenticated-orcid":false,"given":"Brian","family":"O'Donoghue","sequence":"first","affiliation":[{"name":"Centre for Youth Mental Health University of Melbourne  Victoria Australia"},{"name":"Orygen  Parkville Victoria 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