{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:15:24Z","timestamp":1788552924759,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Opioid use disorder (OUD) is a leading cause of preventable mortality amongst young people worldwide. Early identification and intervention of modifiable risk factors may reduce future OUD risk. The aim of this study was to explore whether the onset of OUD is associated with preexisting mental health conditions such as anxiety and depressive disorders in young people.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, population\u2010based case\u2010control study was conducted from 31 March 2018 until 01 January 2002. Provincial administrative health data were collected from Alberta, Canada. Cases: Individuals 18\u201325\u2009years on 01 April 2018, with a previous record of OUD. Controls: Individuals without OUD were matched to cases, on age\/sex\/index date. Conditional logistic regression analysis was used to control for additional covariates (e.g., alcohol\u2010related disorders, psychotropic medications, opioid analgesics, and social\/material deprivation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u20091848 cases and\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u20097392 matched controls. After adjustment, OUD was associated with the following preexisting mental health conditions: Anxiety disorders, aOR\u00a0=\u00a02.53 (95% CI\u00a0=\u00a02.16\u20132.96); depressive disorders, aOR\u00a0=\u00a02.20 (95% CI\u00a0=\u00a01.80\u20132.70); alcohol\u2010related disorders, aOR\u00a0=\u00a06.08 (95% CI, 4.86\u20137.61); anxiety and depressive disorders, aOR\u00a0=\u00a01.94 (95% CI\u00a0=\u00a01.56\u20132.40); anxiety and alcohol\u2010related disorders, aOR\u00a0=\u00a05.22 (95% CI\u00a0=\u00a04.03\u20136.77); depressive and alcohol\u2010related disorders, aOR\u00a0=\u00a06.47 (95% CI\u00a0=\u00a04.73\u20138.84); anxiety, depressive and alcohol\u2010related disorders, aOR\u00a0=\u00a06.09 (95% CI\u00a0=\u00a04.41\u20138.42).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Preexisting mental health conditions such as anxiety and depressive disorders are risk factors for future OUD in young people. Preexisting alcohol\u2010related disorders showed the strongest association with future OUD and demonstrated an additive risk when concurrent with anxiety\/depression. As not all plausible risk factors could be examined, more research is still needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eip.13385","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T23:54:57Z","timestamp":1676505297000},"page":"963-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preexisting mental health disorders and risk of opioid use disorder in young people: A case\u2010control study"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-3639","authenticated-orcid":false,"given":"Tyler","family":"Marshall","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine &amp; Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Olson","sequence":"additional","affiliation":[{"name":"Faculty of Nursing University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Youngson","sequence":"additional","affiliation":[{"name":"Health Research Methods and Analytics Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Abba\u2010Aji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine &amp; Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine &amp; Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Vohra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine &amp; Dentistry University of Alberta  Edmonton Alberta Canada"},{"name":"Department of Pediatrics, Faculty of Medicine &amp; Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lewanczuk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine &amp; Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.1048"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000606"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.1712"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-072X-6-50"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00314-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19m12775"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19042230"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170958"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-021-01249-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170363"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2017.05.030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30337-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00508-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2009.07.004"},{"key":"e_1_2_9_16_1","first-page":"223","volume-title":"Contemporary directions in psychopathology: Scientific foundations of the DSM\u2010V and ICD\u201011","author":"Eaton N. 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