{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:04:58Z","timestamp":1780394698435,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to identify clinical and socio\u2010demographic factors associated with duration of untreated illness (DUI) in patients affected by panic disorder (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from patients' medical records (<jats:italic>N<\/jats:italic>\u2009=\u2009157) of two mental health services respectively located in Milan and in Monza (Italy). Correlation analyses and analysis of variance (ANOVAs) were run to analyse the relation between DUI and quantitative\/qualitative variables respectively. Statistically significant variables in uni\u2010 variate analyses were then inserted in a linear multivariable regression model (backward procedure).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean DUI was 27.33 (<jats:italic>\u00b1<\/jats:italic>50.56) months. Patients with an earlier age at onset (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.270; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), a longer duration of illness (<jats:italic>r<\/jats:italic>\u2009=\u20090.483; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) and who received a lifetime psychotherapy (<jats:italic>F<\/jats:italic>\u2009=\u20096.86; <jats:italic>p<\/jats:italic>\u2009=\u2009.01) had a longer DUI. The final global model showed that a longer DUI was associated with pre\u2010onset poly\u2010substance misuse (<jats:italic>p<\/jats:italic>\u2009=\u2009.05) and a longer duration of illness (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of our study showed that a longer DUI was predicted by clinical factors such as the presence of a pre\u2010onset poly\u2010substance use disorder and that delayed proper treatment can lead to a chronicization of PD, as indicated by a longer duration of illness. Further studies are needed to in\u2010depth investigate the role of DUI in influencing the course and outcome of anxiety disorders, including PD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.13506","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T10:30:31Z","timestamp":1707993031000},"page":"633-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Which clinical factors delay proper treatment in panic disorder? A cross\u2010sectional multicentric study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5627-7218","authenticated-orcid":false,"given":"T.","family":"Surace","sequence":"first","affiliation":[{"name":"Department of Mental Health and Addiction Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3359-3191","authenticated-orcid":false,"given":"M.","family":"Buoli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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