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The 16\u2010item version of the Prodromal Questionnaire (PQ\u201016) is a worldwide used self\u2010administered tool for this purpose. However, to date, fundamental psychometric properties of PQ\u201016 were not thoroughly investigated. This study aimed to examine the structural validity, measurement invariance, reliability and other psychometrical properties of the Italian version of the PQ\u201016 (iPQ\u201016) in help\u2010seeking individuals and in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The iPQ\u201016 was administered to 449 young outpatients attending six community mental health services and to 318 control participants enrolled in educational environment. Confirmatory factor analyses (CFAs), measurement invariance (MI) between the help\u2010seeking group and the general population sample, convergent validity, test\u2013retest reliability, internal consistency, and prevalence analyses were performed. Lastly, the validity of the adopted PQ\u201016 cut\u2010offs through Receiver Operating Characteristic (ROC) curves plotted against CAARMS diagnoses was also tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CFAs confirmed the single\u2010factor structure for the iPQ\u201016 and scalar MI was reached. The iPQ\u201016 showed high internal consistency, test\u2013retest reliability, convergent validity, and acceptable diagnostic accuracy. ROC analysis suggested a score of \u22654 as best cut\u2010off.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The iPQ\u201016 represents a valid and reliable questionnaire for the assessment of high mental risk in both Italian outpatients and general student population. It has good psychometric properties and is easy to implement as UHR screening for clinical as well as research purposes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.13516","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:30:20Z","timestamp":1708428620000},"page":"814-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The <scp>Italian<\/scp> version of the 16\u2010item <scp>Prodromal Questionnaire<\/scp> (<scp>PQ<\/scp>\u201016) and its psychometric features in help\u2010seeking ultra\u2010high\u2010risk subjects and in the general population"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2898-5134","authenticated-orcid":false,"given":"Alberto","family":"Parabiaghi","sequence":"first","affiliation":[{"name":"Department of Health Policy, Unit for Quality of Care and Rights Promotion in Mental Health Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-5999","authenticated-orcid":false,"given":"Alessandro Alberto","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology University of Padova  Padova Italy"},{"name":"Interdepartmental Center for Family Research University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8875-9657","authenticated-orcid":false,"given":"Anna","family":"Castelnovo","sequence":"additional","affiliation":[{"name":"Sleep Medicine Unit Neurocenter of Southern Switzerland  Lugano Switzerland"},{"name":"Faculty of Biomedical Sciences Universit\u00e0 della Svizzera Italiana  Lugano Switzerland"},{"name":"University Hospital of Psychiatry and Psychotherapy University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1452-9688","authenticated-orcid":false,"given":"Lorenzo","family":"del Fabro","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan Italy"},{"name":"Department of Neurosciences and Mental Health, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8446-785X","authenticated-orcid":false,"given":"Stefania","family":"Mannarini","sequence":"additional","affiliation":[{"name":"Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology University of Padova  Padova Italy"},{"name":"Interdepartmental Center for Family Research University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Emilio","family":"Percudani","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico University of Milan  Milan Italy"},{"name":"Department of Mental Health and Addiction Services ASST Grande Ospedale Metropolitano \"Niguarda\"  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the CCM2013 Project team (corporate authorship)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859x-10-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0149206313478188"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/3.3.421"},{"key":"e_1_2_9_5_1","first-page":"481","volume-title":"Handbook of international large\u2010scale assessment","author":"Anderson C. 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