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The significant clinical heterogeneity among CHR\u2010P individuals suggests that interventions may need to be personalized during this emerging illness phase. We examined longitudinal trajectories within\u2010persons during treatment to investigate whether baseline factors predict symptomatic and functional outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 36 CHR\u2010P individuals were rated on attenuated positive symptoms and functioning at baseline and each week during CHR\u2010P step\u2010based treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Linear mixed\u2010effects models revealed that attenuated positive symptoms decreased during the study period, while functioning did not significantly change. When examining baseline predictors, a significant group\u2010by\u2010time interaction emerged whereby CHR\u2010P individuals with more psychiatric comorbidities at baseline (indicating greater clinical complexity) improved in functioning during the study period relative to CHR\u2010P individuals with fewer comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individual differences in clinical complexity may predict functional response during the early phases of CHR\u2010P treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.13590","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:11:41Z","timestamp":1720656701000},"page":"888-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The influence of complex psychiatric comorbidities on treatment for clinical high\u2010risk for psychosis: A preliminary study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6814-2628","authenticated-orcid":false,"given":"Aubrey M.","family":"Moe","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"},{"name":"Department of Psychology The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry R.","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Manges","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-6926","authenticated-orcid":false,"given":"Heather M.","family":"Wastler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Kilicoglu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9877-3719","authenticated-orcid":false,"given":"Nicholas J. 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