{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:26:41Z","timestamp":1771460801006,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bipolar disorder (BD) is a severe, persistent disorder that causes functional impairment. Besides heritability, environmental factors, such as traumatic experience, impact the development of BD. Little is known about the early developmental signs of this disorder; therefore, this study aims to look at the impact of interpersonal trauma on the early developmental signs of BD. Specifically, differences in psychopathological behaviours were investigated between (1) at\u2010risk children and controls and (2) at\u2010risk children who experienced an interpersonal traumatic event and those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Adolescent Brain Cognitive Development (ABCD) dataset, participants with a first\u2010degree relative with BD were identified (<jats:italic>N<\/jats:italic><jats:sub>at\u2010risk<\/jats:sub>\u2009=\u2009625) and matched on sex and age to a control group (<jats:italic>N<\/jats:italic><jats:sub>control<\/jats:sub>\u2009=\u2009625). The Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS) was used to assess interpersonal trauma and psychopathological symptoms. The trauma (<jats:italic>N<\/jats:italic><jats:sub>trauma<\/jats:sub>\u2009=\u2009198) and no\u2010trauma sub\u2010groups (<jats:italic>N<\/jats:italic><jats:sub>no\u2010trauma<\/jats:sub>\u2009=\u2009428) were built from the at\u2010risk population. Group comparison was conducted on depressive, manic and anxiety symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, at\u2010risk children exhibited a significantly greater number of manic symptoms at baseline and 2\u2010year follow\u2010up, and anxiety symptoms at follow\u2010up. No significant differences were found between the trauma and no\u2010trauma groups at either baseline or follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results confirm the presence of early symptoms in at\u2010risk children, in line with the staging model of BD. Extended longitudinal research is needed to further investigate the potential specific role of trauma on its early behavioural patterns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eip.70058","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T10:58:23Z","timestamp":1748602703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring Behavioural Patterns in Youth Predisposed to Bipolar Disorder and the Role of Interpersonal Trauma Using the Adolescent Brain Cognitive Development (<scp>ABCD<\/scp>) Dataset"],"prefix":"10.1111","volume":"19","author":[{"given":"Christina","family":"Ghaleb","sequence":"first","affiliation":[{"name":"Douglas Research Center  Montreal Quebec Canada"},{"name":"Department of Psychology McGill University  Montreal Quebec 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