{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:34:41Z","timestamp":1775057681183,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100022979","name":"Gandel Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022979","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Both substance use and mental illness commonly onset during adolescence or young adulthood, and rates of substance use in young people with mental illness are disproportionately high. This baseline data paper from a clinical trial testing an integrated early intervention for substance use and mental health problems aims to (1) describe the characteristics of participants enrolled and (2) compare young people with a current and without a lifetime diagnosis of substance use disorder (SUD) in terms of psychiatric symptoms, functioning, and substance use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010nine participants aged 12\u201325\u2009years with high prevalence mental illness (e.g., depression, anxiety) and substance use seeking mental healthcare were recruited from headspace primary mental health centres in North\u2010Western Melbourne. At baseline, they completed self\u2010report and interview measures of psychiatric diagnoses and symptoms, functioning, and substance use. We compared those with a current (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951) and without a lifetime (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921) SUD on these measures. This is a secondary data analysis of baseline data for the INTEGRATE clinical trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Youth with an SUD endorsed more severe depressive and anxiety symptoms, and lower quality of life and role functioning than those who used substances without a lifetime SUD. They also had more alcohol\u2010related problems and higher frequency cannabis use and higher risk scores for alcohol, tobacco, cannabis, cocaine, amphetamine\u2010type stimulants and hallucinogen use. There were no group differences in social and occupational functioning or subjectively rated sleep quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings highlight the need for early identification and integrated care models within youth mental health services to address the high prevalence and impact of substance use, potentially reducing adverse effects of co\u2010occurring SUD and mental illness on youth development and functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The study was preregistered (ACTRN12619001522101)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eip.70106","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T01:15:14Z","timestamp":1764551714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics of Youth With Recent Substance Use With and Without Substance Use Disorder Presenting for Primary Mental Healthcare in Australia: Baseline Findings From the\n                    <scp>INTEGRATE<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-2656","authenticated-orcid":false,"given":"Ellie","family":"Ahounbar","sequence":"first","affiliation":[{"name":"Centre for Youth Mental Health University of Melbourne and Orygen  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-3620","authenticated-orcid":false,"given":"Alexandre 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-622X","authenticated-orcid":false,"given":"Andrew","family":"Chanen","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health University of Melbourne and Orygen  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-1405","authenticated-orcid":false,"given":"Sarah","family":"Clarke","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health University of Melbourne and Orygen  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3456-1610","authenticated-orcid":false,"given":"Amelia","family":"Quinn","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health University of Melbourne and Orygen  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1467-6020","authenticated-orcid":false,"given":"Shelley","family":"Baird","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health University of Melbourne and Orygen  Melbourne Australia"},{"name":"School of Population and Global Health University of Western Australia  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-5551","authenticated-orcid":false,"given":"E\u00f3in","family":"Killackey","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health University of Melbourne and Orygen  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-6168","authenticated-orcid":false,"given":"Patrick","family":"McGorry","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health University of Melbourne 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