{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T02:42:27Z","timestamp":1776998547090,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Predicting prognosis in subjects at Clinical High Risk for Psychosis (CHR\u2010P) is still challenging. In particular, there are some disregarded factors such as ongoing Antipsychotic (AP) treatment that potentially induce method errors and research bias. The specific purpose of this examination was to examine whether baseline AP exposure and its dosage identify different CHR\u2010P groups with diverse prognostic outcomes across 2\u2009years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>182 CHR\u2010P participants (93 AP\u2010na\u00efve, 60 low\u2010dose AP, 33 high\u2010dose AP) were assessed for a broad range of clinical outcomes, including psychosis transition, clinical and functional remission (measured with the Positive and Negative Syndrome Scale and the Social and Occupational Functioning Assessment Scale). Inter\u2010group comparisons were explored using Kaplan\u2013Meier survival analyses and binary logistic regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across the follow\u2010up, the high\u2010dose AP subgroup showed an increased risk of new hospitalisation and poorer functional remission compared to AP\u2010na\u00efve participants. Conversely, the low\u2010dose AP subsample had a higher 2\u2010year rate of symptomatic remission and a lower 2\u2010year rate of self\u2010harm behaviour compared to AP\u2010na\u00efve one.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>APs at low doses are associated with better symptomatic outcomes, whilst APs at high doses correlate to poorer socio\u2010occupational functioning. Promoting personalised treatment strategies and facilitating the identification of specific CHR\u2010P subgroups with divergent prognoses are recommended in clinical practise.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eip.70167","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T02:33:27Z","timestamp":1774233207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exposure to Antipsychotics in Youths at Clinical High Risk for Psychosis: Low\n                    <scp>VS<\/scp>\n                    High Doses and Their Relevance for Clinical Outcomes"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4746-2061","authenticated-orcid":false,"given":"Lorenzo","family":"Pelizza","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum\u2014Universit\u00e0 di Bologna  Bologna 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