{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:05:27Z","timestamp":1783911927188,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PE0000006"],"award-info":[{"award-number":["PE0000006"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the association between cannabis use prior to enrollment in a First Episode Psychosis (FEP) program and prognosis, including severity of psychiatric symptoms, type of antipsychotic treatment prescribed, and clinical recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A longitudinal cohort study was conducted on patients aged 18\u201335 diagnosed with affective and non\u2010affective psychosis who were referred to the FEP Program in Ferrara, Italy,\u00a0between 2012 and April 2024. Sociodemographic and clinical data were collected at program entry and every six months for up to 24\u2009months. Cannabis use was categorised dichotomously based on reported or charted use within the month prior to program entry. The Health of the Nation Outcome Scale (HoNOS) was used to monitor clinical outcomes (assessed through reductions of the total HoNOS score, employment status, and type of antipsychotic prescription) and recovery (total HoNOS &lt;\u20098). Bivariate analyses compared sociodemographic characteristics and clinical outcomes between people with cannabis use and people without cannabis use at baseline and at 1\u2010 and 2\u2010year follow\u2010ups, considering both baseline cannabis status and current cannabis use status. A Mixed Model for Repeated Measures, was used to compare the average HoNOS scores and the recovery rates between the two groups at several endpoints (baseline, 12\u2009months and 24\u2009months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total sample included 173 patients, predominantly men (74.5%), diagnosed with non\u2010affective psychosis (83.8%), with a median age at onset of psychotic symptoms of 22.9\u2009years. At admission, individuals reporting cannabis use (48%), compared to those without cannabis use, were predominantly male (87.9% vs. 62.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), had a significantly shorter duration of untreated psychosis (32.8 vs. 52.2\u2009weeks,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) and were more likely to receive combined oral and depot antipsychotic treatment (16.9% vs. 5.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05), no difference in baseline HoNOS scores was observed. At 1\u2010 and 2\u2010year follow\u2010ups, no significant differences in overall psychopathology were found between groups under either cannabis use condition. However, baseline cannabis exposure was associated with lower rates of student status at both 1\u2010year (11.8% vs. 24.3%) and 2\u2010year (6.3% vs. 23.2%) follow\u2010ups. At the 1\u2010year follow\u2010up, participants with cannabis use were more likely to receive a combination of long\u2010acting injectable (LAI) and oral antipsychotics (21.1% vs. 7.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) compared to those without cannabis use. No significant differences were found between the two groups in terms of HoNOS scores or recovery rates at any time point (baseline, 12\u2009months, 24\u2009months).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cannabis use prior to FEP program entry was not associated with significant differences in clinical outcomes or recovery, despite being admitted with a shorter DUP and being\u00a0predominantly male. Nevertheless, cannabis use was associated with more intensive antipsychotic treatment, both at admission and at 1\u2009year. These findings underscore the importance of early detection of cannabis use and integrated care addressing both psychiatric symptoms and substance use. Future randomised controlled trials should explore whether reducing cannabis use can decrease antipsychotic burden and improve long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eip.70179","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:51:07Z","timestamp":1778917867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cannabis Use and Clinical Outcomes in First Episode Psychosis: Results From a 2\u2010Year Follow\u2010Up Study"],"prefix":"10.1111","volume":"20","author":[{"given":"Ilaria","family":"Domenicano","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Onofrio","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"De Donatis","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Malservigi","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Vincenzo","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino Belvederi","family":"Murri","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, 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