{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T16:27:55Z","timestamp":1787329675820,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH076989"],"award-info":[{"award-number":["U01MH076989"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH081902"],"award-info":[{"award-number":["U01MH081902"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH081928"],"award-info":[{"award-number":["U01MH081928"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH081944"],"award-info":[{"award-number":["U01MH081944"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH081984"],"award-info":[{"award-number":["U01MH081984"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH081988"],"award-info":[{"award-number":["U01MH081988"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH082004"],"award-info":[{"award-number":["U01MH082004"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["U01MH082022"],"award-info":[{"award-number":["U01MH082022"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["UO1MH081857"],"award-info":[{"award-number":["UO1MH081857"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Posttraumatic stress disorder (PTSD) is a common comorbid diagnosis in psychotic disorders. However, little is known about the effect of comorbid PTSD in youth at clinical high risk (CHR) for psychosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate group differences in symptom severity, risk for psychotic conversion and functioning among youth at CHR for psychosis with and without PTSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This longitudinal study utilized data from\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009693 individuals who met criteria for CHR as part of the North American Prodrome Longitudinal Study 3 (NAPLS\u20103). Individuals who met criteria for PTSD were compared to those who did not meet criteria for PTSD on demographic, symptom and functional variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Individuals diagnosed with PTSD (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200954) reported more severe overall positive symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), negative symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043) and general symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) compared to those without the diagnosis (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009639). These symptom differences were primarily accounted for by more grandiose symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), decreased experience of emotions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043), sleep disturbance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043), dysphoric mood (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) and impaired tolerance to stress (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) in those with PTSD. In Cox proportional hazards models using the full sample with censoring at last follow\u2010up, PTSD diagnosis was not associated with time to psychosis conversion. Exploratory analyses of trauma subtype within the PTSD group also did not identify any trauma category significantly associated with conversion risk. Timing of trauma exposure (early childhood, middle childhood, adolescence) was not significantly associated with conversion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that a diagnosis of PTSD is associated with more severe overlapping symptoms in individuals meeting the criteria for CHR but not psychotic conversion. Our findings underscore the importance of recognizing and treating comorbid psychiatric conditions including PTSD in CHR populations as a means of reducing symptoms and improving outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eip.70188","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:36:00Z","timestamp":1782311760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Group Differences in Attenuated Symptoms and Functioning Between Clinical High\u2010Risk Individuals With and Without Posttraumatic Stress Disorder"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5541-7749","authenticated-orcid":false,"given":"Danielle","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Public Health UCSD  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leda","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry UCSD  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-0756","authenticated-orcid":false,"given":"Jean","family":"Addington","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hotchkiss Brain Institute, University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie E.","family":"Bearden","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5632-3154","authenticated-orcid":false,"given":"Tyrone D.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Psychology Yale University  New Haven Connecticut USA"},{"name":"Department of Psychiatry Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Cornblatt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Zucker Hillside Hospital  Long Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matcheri","family":"Keshavan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Mathalon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry UCSF  San Francisco California USA"},{"name":"SFVA Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana O.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-8101","authenticated-orcid":false,"given":"Elaine F.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Psychology and Psychiatry Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-5228","authenticated-orcid":false,"given":"Scott W.","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-4605","authenticated-orcid":false,"given":"Kristin S.","family":"Cadenhead","sequence":"additional","affiliation":[{"name":"Department of Psychiatry UCSD  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010016\u20100827\u20104"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.04.029"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2020.04.010"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.03.043"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010021\u201001155\u20107"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22916"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.2010.01542.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.03.085"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010022\u201002239\u20105"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20103223(95)00314\u20102"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbm029"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.103651"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.10.012"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/eip.13270"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.1472"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.2007.01011.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.09.006"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1581756"},{"key":"e_1_2_12_21_1","volume-title":"Trauma and Recovery: Aftermath of Violence From Domestic Abuse to Political Terror","author":"Herman J. L.","year":"2015"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21466"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12091169"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.04.006"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2678"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.11.014"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40653\u2010018\u20100212\u20101"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa037"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0018477"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00055"},{"key":"e_1_2_12_31_1","volume-title":"The Psychosis\u2010Risk Syndrome: Handbook for Diagnosis and Follow\u2010Up","author":"McGlashan T. H.","year":"2010"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12565"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1348\/014466503322528892"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.147926"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000523"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2017.1351204"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.25177"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.08.028"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20040"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000092177.97317.26"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2022.0353"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.05.004"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.12.005"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2015.03.014"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs050"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171500135X"}],"container-title":["Early Intervention in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.70188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eip.70188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.70188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:28:37Z","timestamp":1787326117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.70188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/eip.70188"],"URL":"https:\/\/doi.org\/10.1111\/eip.70188","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.172504879.96024747\/v1","asserted-by":"object"}]},"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]},"assertion":[{"value":"2024-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70188"}}