{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:44:40Z","timestamp":1792215880694,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Childhood\u2010onset Obsessive\u2010Compulsive Disorder (OCD) has been associated with an increased vulnerability to psychosis, yet no prospective studies have examined this risk in paediatric populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this pilot prospective study, 59 adolescents with a primary diagnosis of OCD were assessed at baseline for psychotic vulnerability, measured through Cognitive\u2010Perceptual basic symptoms (COPER) and the high\u2010risk criterion Cognitive Disturbances (COGDIS), as well as for OCD severity and psychosocial functioning. The number of subjects who developed a first episode of psychosis (FEP) during the 18\u2010month follow\u2010up period was evaluated. Logistic regression and moderation analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the follow\u2010up period, 18.6% of participants presented with a FEP. These patients were older and displayed poorer psychosocial functioning compared with those who did not develop a FEP. Logistic regression identified higher COPER symptoms and lower psychosocial functioning as the only significant predictors of FEP. Although moderation effects were not statistically significant, exploratory simple slopes suggested that both COPER and COGDIS symptoms were more strongly associated with psychosis onset in adolescents with lower psychosocial functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights a notable rate of progression to psychosis among adolescents with OCD over an 18\u2010month period. Despite methodological limitations, our findings offer preliminary evidence that COPER symptoms and impaired psychosocial functioning are key risk factors in adolescents with OCD for progression to psychosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eip.70244","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:54:14Z","timestamp":1785934454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychotic Vulnerability in Adolescents With Obsessive\u2010Compulsive Disorder: First Longitudinal Evidence From a Prospective Pilot Study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-9100","authenticated-orcid":false,"given":"Davide Fausto","family":"Borrelli","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, Psychiatry Unit University of Parma Parma Italy"},{"name":"Department of Mental Health AUSL of Piacenza Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6468-9471","authenticated-orcid":false,"given":"Luca","family":"Gambol\u00f2","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Psychiatry Unit University of Parma Parma Italy"},{"name":"Department of Mental Health AUSL of Piacenza Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Donna","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Psychiatry Unit University of Parma Parma Italy"},{"name":"Department of Mental Health AUSL of Piacenza Piacenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Marchesi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Psychiatry Unit University of Parma Parma Italy"},{"name":"Department of Mental Health AUSL of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-9586","authenticated-orcid":false,"given":"Matteo","family":"Tonna","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Psychiatry Unit University of Parma Parma Italy"},{"name":"Department of Mental Health AUSL of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Integrative Guide for the 1991 CBCL\/4\u201018, YSR, and TRF Profiles","author":"Achenbach T. 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