{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:00:21Z","timestamp":1791475221066,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024749","name":"National Institute for Health Research Applied Research Collaboration East of England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024749","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Early Intervention Psych"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Early Intervention in Psychosis services were established throughout England over two decades ago, yet despite aiming to optimise care, less than 40% of patients achieve full clinical recovery and notable inequities persist in accessing NICE\u2010recommended treatments. Fragmented electronic health record systems and limited systematic data capture conceal how disparities in care delivery and effectiveness affect recovery and remission. The Early Psychosis Informatics into Care, EPICare, programme aims to develop a national, learning healthcare system incorporating a standardised core dataset and clinician dashboard to support equitable, data\u2010driven care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our stakeholder co\u2010design approach comprised three interlinked work packages delivered between 2021 and 2022. Using participatory co\u2010design, we conducted four multi\u2010stakeholder workshops and preparatory lived experience sessions with people with lived experience, clinicians, informaticians, academics, and policymakers. We identified essential data elements using adapted \u201cMoSCoW\u201d card sort methodology, refined content, and developed dashboard requirements. Parallel informatics and implementation research assessed technical feasibility, data maturity, and harmonisation requirements and evaluated anticipated barriers and facilitators to future adoption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Consensus was achieved on core EPICare dataset \u201cmust haves\u201d including sociodemographic variables, routine treatment interventions, Patient\u2010 and Clinician\u2010Reported Outcome Measures, and longitudinal symptom data. Stakeholders defined key dashboard features, prioritising usability and alignment with clinical workflow. Substantial variation in Trust\u2010level data infrastructure informed flexible technical architecture to mitigate implementation risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EPICare stakeholder engagement delivered the blueprint for a co\u2010designed, technically feasible and nationally scalable specification for a psychosis learning healthcare system, enabling progression to platform development and piloting across five Early Intervention in Psychosis services in the NHS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/eip.70264","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:35:34Z","timestamp":1789979734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Stakeholder\u2010Informed Approach to the Development and Implementation of National Digital Registry and Learning Healthcare System (\n                    <scp>LHS<\/scp>\n                    ) for Psychosis: Findings From the\n                    <scp>EPICare<\/scp>\n                    Platform"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8204-5103","authenticated-orcid":false,"given":"Rachel","family":"Upthegrove","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Oxford  Oxford UK"},{"name":"Institute for Mental Health University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-7779","authenticated-orcid":false,"given":"Melanie","family":"Lafanechere","sequence":"additional","affiliation":[{"name":"Division of Psychiatry UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5162-0937","authenticated-orcid":false,"given":"Megan A.","family":"Pope","sequence":"additional","affiliation":[{"name":"Institute for Mental Health University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4547-9429","authenticated-orcid":false,"given":"India","family":"Francis\u2010Crossley","sequence":"additional","affiliation":[{"name":"Division of Psychiatry UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2187-9195","authenticated-orcid":false,"given":"John","family":"Ainsworth","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine and Health, Division of Informatics, Imaging and Data Science, School of Health Sciences The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3601-0580","authenticated-orcid":false,"given":"Sophie M.","family":"Allan","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapies University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tumelo","family":"Bogatsu","sequence":"additional","affiliation":[{"name":"Institute for Mental Health University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-025X","authenticated-orcid":false,"given":"Niyah","family":"Campbell","sequence":"additional","affiliation":[{"name":"Institute for Mental Health University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-4835","authenticated-orcid":false,"given":"Richard J.","family":"Drake","sequence":"additional","affiliation":[{"name":"Division of Psychology and Mental Health The University of Manchester  Manchester UK"},{"name":"Greater Manchester Mental Health NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-1384","authenticated-orcid":false,"given":"Sonia","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Psychiatry UCL  London UK"},{"name":"North London Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1301-3359","authenticated-orcid":false,"given":"Mohammad Zia Ul Haq","family":"Katshu","sequence":"additional","affiliation":[{"name":"Institute of Mental Health University of Nottingham  Nottingham UK"},{"name":"Nottinghamshire Healthcare NHS Foundation Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8296-1742","authenticated-orcid":false,"given":"Graham K.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  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National Institute for Health and Care Excellence.https:\/\/www.nice.org.uk\/guidance\/qs80."},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719004100"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1192\/BJO.2018.50"},{"key":"e_1_2_11_34_1","volume-title":"State of the Nation Report: Audit of Early Intervention in Psychosis Provision in England and Wales in 2022\/2023 and 2023\/2024","author":"Royal College of Psychiatrists","year":"2025"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115529"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.12127"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1192\/BJO.2020.89"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx196"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1751\u20107893.2012.00389.X"}],"container-title":["Early Intervention in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.70264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/eip.70264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eip.70264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:38:07Z","timestamp":1791473887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eip.70264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/eip.70264"],"URL":"https:\/\/doi.org\/10.1111\/eip.70264","archive":["Portico"],"relation":{},"ISSN":["1751-7885","1751-7893"],"issn-type":[{"value":"1751-7885","type":"print"},{"value":"1751-7893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70264"}}