{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:27:47Z","timestamp":1697603267606},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serological analyses within epidemiological cohort and case\u2010control studies indicate to an association between <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection and risk of multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>). To verify the relationship with an independent approach, we investigated the correlation between <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> positivity and chromosomal aberrations within 680 patients of the National Center for Tumor Diseases Heidelberg for which the serological <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> status (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg and anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>c) and <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> data for five gains (1q21, 9q34, 11q23, 15q22, 19q13), five losses (6q21, 8p21, 13q14, 17p13, 22q11), and three IgH translocations [t(4,14), t(11,14), t(14,16)] were available. Deletion of 8p21 and 13q14 were shown associated with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> positivity within hepatocellular carcinoma in other investigations. In the present evaluation, the odds ratio for loss of 8p21 was significantly elevated (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.74, 95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00a0=\u00a01.36\u20135.50, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0048) and for loss of 13q14 non\u2010significantly increased (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.40, 95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\u00a0=\u00a00.74\u20132.65) in anti\u2010<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>c positive patients. The results provide further support for a role of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infection in the pathogenesis of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ejh.12018","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T14:03:10Z","timestamp":1349272990000},"page":"279-285","source":"Crossref","is-referenced-by-count":2,"title":["Hepatitis <scp>B<\/scp> virus infection is associated with deletion of chromosome 8p in multiple myeloma"],"prefix":"10.1111","volume":"90","author":[{"given":"Nikolaus","family":"Becker","sequence":"first","affiliation":[{"name":"Clinical Cancer Registry National Center of Tumor Diseases and German Cancer Research Center Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Byl","sequence":"additional","affiliation":[{"name":"Clinical Cancer Registry National Center of Tumor Diseases and German Cancer Research Center Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Clinical Cancer Registry National Center of Tumor Diseases and German Cancer Research Center Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jauch","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Virology University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlinde","family":"Egerer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V University of Heidelberg and National Center for Tumor Diseases Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Neben","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V University of Heidelberg Heidelberg 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