{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:22:21Z","timestamp":1787314941598,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T00:00:00Z","timestamp":1355443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mantle cell lymphoma (\n                    <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                    ) is an aggressive\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    \u2010cell non\u2010Hodgkin lymphoma (\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    ) characterized by the translocation t(11;14)(q13;q32). This lymphoma exhibits a poor prognosis and remains incurable with standard chemotherapy approaches. Recently, we have shown that a majority of patients with acute\u2010type adult\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    \u2010cell leukemia\/lymphoma (\n                    <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>\n                    ) have multiple subclones that were likely produced in lymph nodes. We investigated whether\n                    <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                    has multiple subclones as identified in\n                    <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>\n                    by high\u2010resolution oligo\u2010array comparative genomic hybridization (\n                    <jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content>\n                    ). Eleven of 20 (55%) evaluable\n                    <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                    cases had a log2 ratio imbalance, suggesting the existence of multiple subclones in\n                    <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                    . Based on the proportion of every subclone relative to the main clone, we were able to speculate clonal evolution in each\n                    <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                    case with multiple subclones. Our analysis gave new insights into the clonal heterogeneity quantitatively and accurately. Furthermore, genomic copy number alterations are not hierarchical events and not necessarily the initial or later events for cells to become\n                    <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/ejh.12030","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T04:04:54Z","timestamp":1351569894000},"page":"51-58","source":"Crossref","is-referenced-by-count":18,"title":["Clonal heterogeneity of mantle cell lymphoma revealed by array comparative genomic hybridization"],"prefix":"10.1111","volume":"90","author":[{"given":"Fang","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan"},{"name":"Department of Pathology Tongji Hospital Tongji University School of Medicine Shanghai 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