{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:38:08Z","timestamp":1762875488466},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To prospectively investigate iron homeostasis in full\u2010term intrauterine growth\u2013restricted (IUGR) and appropriate\u2010for\u2010gestational\u2010age (AGA) infants at birth, by evaluating cord blood concentrations of hepcidin (a bioactive molecule, principal regulator of iron metabolism, downregulated by hypoxia\/iron deficiency and upregulated by inflammation), erythropoietin (EPO, a marker of prolonged fetal hypoxia), soluble transferrin receptor (<jats:styled-content style=\"fixed-case\">sTfR<\/jats:styled-content>, a marker of increased erythropoiesis and tissue iron deficiency), iron, ferritin, and unsaturated iron\u2010binding capacity (UIBC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum cord blood samples from 47 well\u2010defined <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content> and 104 <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content> singleton, full\u2010term infants were analyzed for concentrations of all the aforementioned parameters by enzyme immunoassays and spectrophotometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hepcidin concentrations were similar, while EPO concentrations were higher in IUGR cases than in AGA controls (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.047). Cord blood <jats:styled-content style=\"fixed-case\">sTfR<\/jats:styled-content> concentrations were increased in IUGR, compared to AGA infants (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.004), and negatively correlated with their customized centiles and birth weight (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.238, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.003 and <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.157, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.050, respectively). Ferritin concentrations were lower in IUGR cases than in AGA controls (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.039). In both groups, no correlations were observed between cord blood hepcidin concentrations and iron status indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cord blood hepcidin concentrations in term IUGRs may remain unaffected, possibly due to a balance between hepcidin downregulation by chronic fetal hypoxia (indicated by higher EPO concentrations) and impaired iron metabolism (indicated by lower ferritin and higher <jats:styled-content style=\"fixed-case\">sTfR<\/jats:styled-content> concentrations) on the one hand, and hepcidin upregulation by the inflammatory state characterizing IUGRs, on the other. Furthermore, our findings may possibly indicate the need for regular follow\u2010up for detection of iron\u2010deficient anemia, not only in preterm but also in full\u2010term IUGR neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12035","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T08:42:09Z","timestamp":1351586529000},"page":"37-44","source":"Crossref","is-referenced-by-count":23,"title":["Perinatal role of hepcidin and iron homeostasis in full\u2010term intrauterine growth\u2013restricted infants"],"prefix":"10.1111","volume":"90","author":[{"given":"Despina D.","family":"Briana","sequence":"first","affiliation":[{"name":"Neonatal Division, 2nd Department of Obstetrics and Gynecology Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora","family":"Boutsikou","sequence":"additional","affiliation":[{"name":"Neonatal Division, 2nd Department of Obstetrics and Gynecology Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavroula","family":"Baka","sequence":"additional","affiliation":[{"name":"Neonatal Division, 2nd Department of Obstetrics and Gynecology Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Boutsikou","sequence":"additional","affiliation":[{"name":"Neonatal Division, 2nd Department of Obstetrics and Gynecology Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamprini","family":"Stamati","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry\u2010Molecular Diagnostics, 2nd Department of Pediatrics Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Hassiakos","sequence":"additional","affiliation":[{"name":"Neonatal Division, 2nd Department of Obstetrics and Gynecology Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Gourgiotis","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry\u2010Molecular Diagnostics, 2nd Department of Pediatrics Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadne","family":"Malamitsi\u2010Puchner","sequence":"additional","affiliation":[{"name":"Neonatal Division, 2nd Department of Obstetrics and Gynecology Athens University Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2006.tb00243.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.08.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100805"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.10.009"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80088-4"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000153094"},{"issue":"3","key":"e_1_2_5_8_1","first-page":"R485","article-title":"Fetal iron and cytochrome c status after intrauterine hypoxemia and erythropoietin administration","volume":"262","author":"Georgieff MK","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.53"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00321-3"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1047"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243791"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E07-01-0060"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.027631"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06216.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282f73335"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215686"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-028787"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-139915"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07758.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91342-6"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2657"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.09.019"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-25313"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)90359-4"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.10.032"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.02.003"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2006.10.007"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01479.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90793.2008"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.179"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22773"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.581714"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.022863"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010600629213"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010701391705"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181b91667"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2008.02688.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.013938"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.12.030"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00768.x"},{"key":"e_1_2_5_43_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/ajcn\/64.5.793","article-title":"Refining the assessment of body iron status","volume":"64","author":"Baynes RD","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1309\/7KJ11RX758UKLXXM"},{"key":"e_1_2_5_45_1","first-page":"121","article-title":"Serum ferritin, iron levels and iron binding capacity in asymmetric SGA babies","volume":"43","author":"Karaduman D","year":"2001","journal-title":"Turk J Pediatr"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.536866"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.643328"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01490506"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00363.x"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.84.1.F40"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.1.102.102"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(03)00005-6"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12035","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:49:01Z","timestamp":1700614141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,29]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/ejh.12035"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12035","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,29]]}}}