{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:26:41Z","timestamp":1761895601125},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T00:00:00Z","timestamp":1358640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with poor response acute myeloid leukaemia (AML) generally have a very poor outcome. Allogeneic stem cell transplantation (SCT) is often recommended for these children but the benefit is unclear. The aim of this study was to investigate survival for poor response AML patients treated with SCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Treatment was given according to the NOPHO\u2010AML 2004 protocol. All patients received AIET (Cytarabine, Idarubicin, Etoposide, Thioguanine) and AM (Cytarabine, Mitoxantrone) as induction. We included poor response defined as &gt; 15% blasts on day 15 after AIET (n\u00a0=\u00a017) or &gt; 5% blasts after AM (n\u00a0=\u00a014, refractory disease). Poor response patients received intensively timed induction and proceeded to SCT when a donor was available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one of 267 evaluable patients (12%) had a poor response. SCT was performed in 25; using matched unrelated donors in 13, matched sibling donors in 6, cord blood donor in 4, and haploidentical donor in two. The median follow\u2010up for the 31 poor responding patients was 2.6 years (range 0.4 \u2010 8.1 years) and 3\u2010year probability of survival 70% (95% CI 59\u201077%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The poor responders in the NOPHO\u2010AML 2004 protocol had a favourable prognosis treated with time\u2010intensive induction followed by SCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12051","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T12:17:30Z","timestamp":1354882650000},"page":"187-194","source":"Crossref","is-referenced-by-count":14,"title":["Outcome of poor response paediatric <scp>AML<\/scp> using early <scp>SCT<\/scp>"],"prefix":"10.1111","volume":"90","author":[{"given":"Neval E.","family":"Wareham","sequence":"first","affiliation":[{"name":"Department of Paediatrics The University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Heilmann","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Abrahamsson","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The Queen Silvia Children's Hospital Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Forestier","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Clinical Genetics University of Ume\u00e5 Ume\u00e5 Sweden"},{"name":"Paediatric Haematology and Oncology University Hospital of Ume\u00e5 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Intervention and Technology Karolinska Institutet, Karolinska University Hospital Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shau\u2010Yin","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Queen Mary Hospital and Hong Kong Paediatric Haematology &amp; 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