{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T05:24:13Z","timestamp":1746336253909},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myelodysplastic syndrome (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>) is a clonal disorder arising from an alteration in multipotent stem cells, which lose the ability of normal proliferation and differentiation. Disease progression occurs in approximately 30% <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> cases. Specific chromosomal alterations seem responsible for each step in the evolution of acute myeloid leukemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>). Multiple genetic aberrations occur during the clonal evolution of <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>; however, few studies report the presence of the Philadelphia (Ph) chromosome. We report a rare case of Ph\u2010positive <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>, which evolved during the course of low\u2010risk <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>. The patient, a 76\u2010year\u2010old man with mild leukocytopenia, was diagnosed with <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>, refractory neutropenia (<jats:styled-content style=\"fixed-case\">RN<\/jats:styled-content>). After 1.5\u00a0yr, his peripheral blood and bone marrow were suddenly occupied by immature basophils and myeloblasts, indicating the onset of <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>. A bone marrow smear showed multilineage dysplasia, consistent with <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> evolution. Chromosomal analysis showed an additional t(9;22)(q34;q11) translocation. Because progression occurred concurrently with emergence of the Ph chromosome, we diagnosed this case as Ph\u2010positive <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> with basophilia arising from the clonal evolution of <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>. The patient was initially treated with nilotinib. A hematological response was soon achieved with disappearance of the Ph chromosome in the bone marrow. Emergence of Ph\u2010positive <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> in the course of low\u2010risk <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> has rarely been reported. We report this case as a rare clinical course of <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ejh.12056","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T13:02:36Z","timestamp":1355490156000},"page":"245-249","source":"Crossref","is-referenced-by-count":10,"title":["Abrupt evolution of Philadelphia chromosome\u2010positive acute myeloid leukemia in myelodysplastic syndrome"],"prefix":"10.1111","volume":"90","author":[{"given":"Akiko","family":"Fukunaga","sequence":"first","affiliation":[{"name":"Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Sakoda","sequence":"additional","affiliation":[{"name":"Sumitomo Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shojiro","family":"Inano","sequence":"additional","affiliation":[{"name":"Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Sueki","sequence":"additional","affiliation":[{"name":"Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soshi","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyoshi","family":"Arima","sequence":"additional","affiliation":[{"name":"Kitano Hospital The Tazuke Kofukai Medical Research Institute Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,9]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V63.6.1318.1318"},{"key":"e_1_2_4_3_1","first-page":"127","article-title":"Cytogenetic of myelodysplastic syndromes","volume":"33","author":"Fenaux P","year":"1996","journal-title":"Semin Hematol"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2005.08.006"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2003.10.027"},{"key":"e_1_2_4_6_1","first-page":"907","article-title":"Characterization of Philadelphia\u2010chromosome\u2010positive acute leukemia by clinical, immunocytochemical, and gene analysis","volume":"6","author":"Tien HF","year":"1992","journal-title":"Leukemia"},{"key":"e_1_2_4_7_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1182\/blood.V36.4.448.448","article-title":"Cytogenetic studies in acute myelocytic leukemia with special emphasis on the occurrence of Ph1 chromosome","volume":"36","author":"Whang\u2010Peng J","year":"1970","journal-title":"Blood"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11477"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/B4NVER1AJJ84CTUU"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08472.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb05565.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V58.1.158.158"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc840"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200107000-00001"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06494"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(97)00262-8"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12056","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T01:35:37Z","timestamp":1697592937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,9]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/ejh.12056"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12056","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,9]]}}}