{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:59:34Z","timestamp":1772819974074,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term outcomes are favorable for patients with polycythemia vera (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) and for patients with essential thrombocythemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>). However, hemorrhage is a significant cause of morbidity and mortality in those patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively recruited 247 patients who had received a diagnosis of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0101) or <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0146) during the period 2001\u20132010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a median follow\u2010up period of 36.2\u00a0months, the cumulative incidence of hemorrhage was 39.6% in patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> (6.2% per person\u2010year) and 29.7% in patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> (5.9% person\u2010years). Episodes of major bleeding occurred in 9.9% of patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and in 14.4% of patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. Overall survival was significantly shorter among patients with hemorrhage than among those without said complication (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.001 for overall patients; <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.002 for patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>;<jats:italic> P\u00a0=\u00a0<\/jats:italic>0.026 for patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>). In the univariate analysis, age \u226560\u00a0yr (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.77, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.046) and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>\u00a0\u2265\u00a016\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.15, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.010) were predictors of hemorrhage in patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, and age \u226560\u00a0yr (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.25, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.040), <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>\u00a0\u2265\u00a016\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.89, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.024), albumin &lt;4.0\u00a0g\/dL (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.10, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002), and splenomegaly (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 5.19, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002) were predictors of hemorrhage in patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. Multivariate analysis showed that <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>\u00a0\u2265\u00a016\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L was the only significant risk factor for hemorrhage in patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.51, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.026) and that splenomegaly was the only risk factor for hemorrhage in patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.00, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Leukocytosis in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and splenomegaly in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> are independent risk factors for hemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12064","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T08:27:46Z","timestamp":1357201666000},"page":"228-236","source":"Crossref","is-referenced-by-count":20,"title":["Leukocytosis in polycythemia vera and splenomegaly in essential thrombocythemia are independent risk factors for hemorrhage"],"prefix":"10.1111","volume":"90","author":[{"given":"Yi\u2010Sheng","family":"Chou","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"National Yang\u2010Ming University School of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyh\u2010Pyng","family":"Gau","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine Taipei Veterans 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