{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:50:25Z","timestamp":1770987025427,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T00:00:00Z","timestamp":1360886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The potency of darbepoetin\u2010\u03b1 (DPO\u2010\u03b1) to improve anemia in hemodialysis (HD) patients is greater than that of recombinant human erythropoietin (<jats:styled-content style=\"fixed-case\">rHuEPO<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>To assess the potency of DPO\u2010\u03b1 to mobilize iron from body stores in comparison with <jats:styled-content style=\"fixed-case\">rHuEPO<\/jats:styled-content> in HD patients without apparent inflammation or infection, serum iron, transferrin saturation (TSAT), ferritin, and hepcidin\u201025 were measured serially. This study included (i) a long\u2010term crossover study for 3\u00a0yr to compare the effects of the two erythropoiesis\u2010stimulating agents (ESA) on serum iron, TSAT, and ferritin, and (ii) a short\u2010term crossover study for 8\u00a0wk to examine their effects on serum hepcidin\u201025 in HD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The long\u2010term crossover study demonstrated that the change of ESA from <jats:styled-content style=\"fixed-case\">rHuEPO<\/jats:styled-content> to DPO\u2010\u03b1 significantly decreased serum ferritin while serum iron and TSAT remained unchanged, while DPO\u2010\u03b1 as well as <jats:styled-content style=\"fixed-case\">rHuEPO<\/jats:styled-content> maintained hemoglobin level in the target range between 10.0 and 11.0\u00a0g\/dL. Furthermore, in the short\u2010term crossover study, area under the percent suppression of serum hepcidin\u201025 time curve for the first 7\u00a0d during the DPO\u2010\u03b1 treatment period was significantly greater than that during the <jats:styled-content style=\"fixed-case\">rHuEPO<\/jats:styled-content> period (348.0\u00a0\u00b1\u00a092.4 vs. 178.4\u00a0\u00b1\u00a0131.5%.day <jats:italic>P\u00a0<\/jats:italic>=\u00a00.030). The greater suppression of hepcidin\u201025 by DPO\u2010\u03b1 may facilitate iron mobilization, resulting in diminution of body iron stores without any significant effect on serum iron utilizable for erythropoiesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that DPO\u2010\u03b1 has a greater advantage than <jats:styled-content style=\"fixed-case\">rHuEPO<\/jats:styled-content> in that it facilitates iron mobilization from body stores into bone marrow to induce effective erythropoiesis and thus could protect against possible harmful effects caused by excessive iron stores in the body.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12067","type":"journal-article","created":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T16:21:35Z","timestamp":1357143695000},"page":"237-244","source":"Crossref","is-referenced-by-count":29,"title":["Greater potency of darbepoetin\u2010<b>\u03b1<\/b> than erythropoietin in suppression of serum hepcidin\u201025 and utilization of iron for erythropoiesis in hemodialysis patients"],"prefix":"10.1111","volume":"90","author":[{"given":"Shigeichi","family":"Shoji","sequence":"first","affiliation":[{"name":"Shirasagi Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine Osaka City University Graduate School of Medicine Osaka Japan"},{"name":"Department of Nephrology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohisa","family":"Tomosugi","sequence":"additional","affiliation":[{"name":"Division of Advanced Medicine Medical Research Institute Kanazawa Medical University Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senji","family":"Okuno","sequence":"additional","affiliation":[{"name":"Shirasagi Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Ichii","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Endocrinology and Molecular Medicine Osaka City University Graduate School of Medicine Osaka Japan"},{"name":"Department of Nephrology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Shirasagi Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Saitama\u2010Tsukinomori Clinic Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2011.00644.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065485"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh1032"},{"issue":"3","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1053\/j.ajkd.2008.11.017","article-title":"KDOQI clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease","volume":"47","author":"National Kidney Foundation","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq760"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005040423"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-010-0288-x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1746"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.22.14.160S.33398"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3319"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm929"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr431"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(82)90404-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320733"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(96)00022-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070802"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2012.01783.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-028787"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05931108"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq099"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008923200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(03)00277-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0584-0"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.526"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2010.00836.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2004.09.018"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.suppl_2.25"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.22433"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000068315.98705.CC"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000035250.66458.67"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T01:35:30Z","timestamp":1697592930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,15]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/ejh.12067"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12067","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,15]]}}}