{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:54:25Z","timestamp":1779306865010,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Beta thalassaemia major (\u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>) and sickle\u2010cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>) are severe haemogobinopathies requiring life\u2010lasting, advanced medical management. In the Mediterranean region, both conditions occur with high frequency. We assessed the efficacy of the National Program for the Prevention of Haemoglobinopathies in Greece during the last 30\u00a0yrs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of affected births between 01\/01\/1980 and 31\/12\/2009 were collected in a nationwide scale, and expected vs. observed rates of new births were calculated and compared. In a subpopulation of affected births of Greek origin, the causes for occurrence of the new affected birth were also collected and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the reduction in new cases was 81.1% and 84.6% for \u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, respectively. For \u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>, a constant declining trend was recorded over the 30\u2010yr period, whereas for <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, a transient reversal was observed in the mid\u20101990s probably due to the significant influx of immigrants of African origin. Programme failure was 2.2\u00a0times more common among new \u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> births of Greek origin compared to new <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> cases (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Unawareness and parental choice were more frequent in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> compared to \u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> (unawareness: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05, parental choice: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). The main cause for programme failure was carrier misidentification and incorrect genetic advice for \u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The \u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> prevention programme in Greece has significantly reduced the numbers of new affected births. The outcomes could be optimised in groups of non\u2010Greek origin, in carrier identification and by offering specialised genetic counselling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12076","type":"journal-article","created":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T07:22:44Z","timestamp":1358580164000},"page":"313-322","source":"Crossref","is-referenced-by-count":36,"title":["Thirty\u2010year experience in preventing haemoglobinopathies in <scp>G<\/scp>reece: achievements and potentials for optimisation"],"prefix":"10.1111","volume":"90","author":[{"given":"Vassilis","family":"Ladis","sequence":"first","affiliation":[{"name":"Department of Haemoglobinopathies The Greek Society of Paediatric Haematology and Oncology Athens Greece"},{"name":"1st Department of Paediatrics University of Athens \u2018Agia Sophia\u2019 Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markissia","family":"Karagiorga\u2010Lagana","sequence":"additional","affiliation":[{"name":"Department of Haemoglobinopathies The Greek Society of Paediatric Haematology and Oncology Athens Greece"},{"name":"Thalassaemia Unit \u2018Agia Sophia\u2019 Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Tsatra","sequence":"additional","affiliation":[{"name":"Department of Haemoglobinopathies The Greek Society of Paediatric Haematology and Oncology Athens Greece"},{"name":"Ippokrateion Hospital University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgos","family":"Chouliaras","sequence":"additional","affiliation":[{"name":"1st Department of Paediatrics University of Athens \u2018Agia Sophia\u2019 Children's Hospital Athens Greece"},{"name":"Biomedical Research Foundation of the Academy of Athens (BRFAA) Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"704","article-title":"Inherited haemoglobin disorders: an increasing global health problem","volume":"79","author":"Weatherall DJ","year":"2001","journal-title":"Bull World Health Organ"},{"key":"e_1_2_8_3_1","first-page":"88","article-title":"The management of thalassaemia. 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