{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:04:12Z","timestamp":1772010252733,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transfusion\u2010acquired hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) remains an important problem among patients with thalassemia. In this study, we evaluated the natural history of post\u2010transfusional hepatitis C in thalassemia major, paying special attention to spontaneous viral clearance, to factors influencing the chronicity rate and fibrosis progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>A prospective study to evaluate the incidence and etiology of transfusion\u2010related hepatitis was started in 1980. In patients who developed hepatitis C, <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ALT<\/jats:styled-content>, and ferritin were measured over time. The correlation between interleukin\u201028B gene polymorphisms and viral clearance was also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three of 135 patients (62.2%) acquired <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. An extended follow\u2010up (22 to 30\u00a0yr) with <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content> assessment was available in 52 patients. Of them, 23 (44.2%) cleared the virus. The proportion of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201028B genotypes was different between the subjects who cleared the virus and the subjects who did not. Fibrosis progression was similar in <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content>\u2013positive and <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content>\u2013negative patients. Liver iron was the only factor associated with the fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In thalassemia patients with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection, liver iron does not play a major role in influencing the chronicity rate, whereas it is significantly associated with the fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12086","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T01:32:49Z","timestamp":1363311169000},"page":"501-507","source":"Crossref","is-referenced-by-count":23,"title":["Natural history of hepatitis C in thalassemia major: a long\u2010term prospective study"],"prefix":"10.1111","volume":"90","author":[{"given":"Maria E.","family":"Lai","sequence":"first","affiliation":[{"name":"Ospedale Regionale per le Microcitemie ASL8 Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Origa","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica 2a Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Danjou","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica 2a Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian B.","family":"Leoni","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica 2a Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Vacquer","sequence":"additional","affiliation":[{"name":"Ospedale Regionale per le Microcitemie ASL8 Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Anni","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica 2a Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Corrias","sequence":"additional","affiliation":[{"name":"Ospedale Regionale per le Microcitemie ASL8 Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Farci","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Congiu","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica 2a Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzo","family":"Galanello","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica 2a Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04077"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180609"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290136"},{"key":"e_1_2_8_5_1","first-page":"9","article-title":"Community acquired and post\u2010transfusion hepatitis C \u201cis there a difference?\u201d","volume":"46","author":"Qureshi AR","year":"1996","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80182-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840070415"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01813.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1182\/blood.V92.9.3460","article-title":"A multicenter prospective study on the risk of acquiring liver disease in anti\u2010hepatitis C virus negative patients affected from homozygous beta\u2010thalassemia","volume":"92","author":"Prati D","year":"1998","journal-title":"Blood"},{"key":"e_1_2_8_10_1","first-page":"1179","article-title":"Clinical and histological characterization of liver disease in patients with transfusion\u2010dependent beta\u2010thalassemia. 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