{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:11:28Z","timestamp":1773403888135,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T00:00:00Z","timestamp":1367539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary hypertension (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) is an increasingly recognized life\u2010threatening complication in sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>), with associated high mortality in adults. The prevalence of <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> in children with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> is still unknown. The etiology and pathophysiologic mechanisms are still not well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the study<\/jats:title><jats:p>To assess the plasma levels of asymmetric dimethylarginine (<jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content>) in children with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> and its correlation with elevated tricuspid regurgitant jet velocity and other hemolytic markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects &amp; Methods<\/jats:title><jats:p>This study was carried out on a cohort of patients (30) with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> and 30 healthy children as a control group. Certain investigations were carried out for all subjects: <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>, lactate dehydrogenase (<jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content>), ferritin, reticulocytic count, bilirubin, <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ALT<\/jats:styled-content>, and plasma levels of <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content>. Doppler echocardiography was carried out for all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of high tricuspid regurgitant velocity (<jats:styled-content style=\"fixed-case\">TRV<\/jats:styled-content>) was 30% in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> patients. <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> mean plasma level was significantly higher in patients than in controls (0.79\u00a0\u00b1\u00a00.15\u00a0\u03bcmol\/L and 0.46\u00a0\u00b1\u00a00.11\u00a0\u03bcmol\/L, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> was significantly higher in patients with high <jats:styled-content style=\"fixed-case\">TRV<\/jats:styled-content> than those with normal <jats:styled-content style=\"fixed-case\">TRV<\/jats:styled-content> (1.10\u00a0\u00b1\u00a00.11\u00a0\u03bcmol\/L, 0.80\u00a0\u00b1\u00a00.06\u00a0\u03bcmol\/L, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). There was a significant positive correlation between <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> plasma levels and <jats:styled-content style=\"fixed-case\">TRV<\/jats:styled-content> \u22652.5\u00a0m\/s (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.475).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High plasma <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> levels may be implicated in the pathogenesis of increased tricuspid regurgitant jet velocity in children with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12114","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T08:36:07Z","timestamp":1364978167000},"page":"55-61","source":"Crossref","is-referenced-by-count":18,"title":["Asymmetric dimethylarginine levels in children with sickle cell disease and its correlation to tricuspid regurgitant jet velocity"],"prefix":"10.1111","volume":"91","author":[{"given":"Mohamed","family":"El\u2010Shanshory","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Tanta Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Badraia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Tanta Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Donia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Tanta Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faten","family":"Abd El\u2010hameed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Tanta Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mokhtar","family":"Mabrouk","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy University of Tanta Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490278402"},{"key":"e_1_2_8_3_1","first-page":"377","article-title":"New pathways to renal damage: role of ADMA in retarding renal disease progression","volume":"23","author":"Ueda S","year":"2010","journal-title":"J Nephrol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.07.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1016\/S0021-9258(18)62716-4","article-title":"Isolation and identification of NG3 NG\u2010 and NG3 WG\u2010dimethylarginine, W\u2010mono\u2010, di\u2010, and trimethyllysine, and glucosylgalactosyl\u2010 and galactosyl\u2010s \u2010hydroxylysine from human urine","volume":"245","author":"Kakimoto Y","year":"1970","journal-title":"J Biol Chem"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90865-Z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.26.061505.111320"},{"key":"e_1_2_8_8_1","first-page":"159","article-title":"Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy","volume":"58","author":"Betowski J","year":"2006","journal-title":"Pharmacol Rep"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(11)60012-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000089087.25930.FF"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2012.04.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035477"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07779.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0983-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07658.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.02.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21184"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000097805.05108.16"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00066.2006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01205.2011"},{"key":"e_1_2_8_21_1","first-page":"RA91","article-title":"Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule","volume":"15","author":"Gennaro Colonna V","year":"2009","journal-title":"Med Sci Monit"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.10.2842S"},{"key":"e_1_2_8_23_1","first-page":"12","article-title":"Asymmetric dimethylarginine \u2013 mechanisms and targets for therapeutic management","volume":"50","author":"Vladimirova\u2010Kitova LG","year":"2008","journal-title":"Folia Med (Plovdiv)"},{"key":"e_1_2_8_24_1","first-page":"284","article-title":"Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production","volume":"18","author":"Pope AJ","year":"2009","journal-title":"J Biol Chem"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2008.1.177"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.1.81"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20000254"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.08.002"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000105764.22626.B1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13812"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010601185892"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11136"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0730"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.11.6"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20791"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000194022.17968.bf"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22195"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.055"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13812"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.030767"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.07.001"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.03.034"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21475"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.04.017"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110727"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3283065bb1"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000085"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010802244035"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005565"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:08:57Z","timestamp":1700676537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,3]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/ejh.12114"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12114","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,3]]}}}