{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:58:43Z","timestamp":1774011523860,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T00:00:00Z","timestamp":1367539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to identify risk factors for acute pulmonary events in children and adolescents in the Pulmonary Hypertension and the Hypoxic Response in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PUSH<\/jats:styled-content>) study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with hemoglobin <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0376) and other sickle cell genotypes (<jats:italic>n<\/jats:italic>\u00a0=\u00a0127) aged 3\u201320\u00a0yrs were studied at four centers in a cross\u2010sectional manner. A subgroup (<jats:italic>n<\/jats:italic>\u00a0=\u00a0293) was followed for a median of 21\u00a0months (range 9\u201335).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A patient\u2010reported history of one or more acute pulmonary events, either acute chest syndrome (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) or pneumonia, was obtained in 195 hemoglobin <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> patients (52%) and 51 patients with other genotypes (40%). By logistic regression, history of acute pulmonary events was independently associated with patient\u2010reported history of asthma (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), older age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), &gt;3 severe pain episodes in the preceding 12\u00a0months (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), higher tricuspid regurgitation velocity (<jats:styled-content style=\"fixed-case\">TRV<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028), and higher white blood cell (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) count (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) among hemoglobin <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> patients. History of acute pulmonary events was associated with &gt;3 severe pain episodes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) among patients with other genotypes. During follow\u2010up, 43 patients (15%) had at least one new <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> episode including 11 without a baseline history of acute pulmonary events. History of acute pulmonary events (odds ratio 5.0; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and younger age (odds ratio 0.9; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) were independently associated with developing a new episode during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Asthma history, frequent pain, and higher values for <jats:styled-content style=\"fixed-case\">TRV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> count were independently associated with history of acute pulmonary events in hemoglobin <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> patients and frequent pain was associated in those with other genotypes. Measures to reduce pain episodes and control asthma may help to decrease the incidence of acute pulmonary events in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12118","type":"journal-article","created":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T06:44:00Z","timestamp":1365230640000},"page":"62-68","source":"Crossref","is-referenced-by-count":34,"title":["Clinical correlates of acute pulmonary events in children and adolescents with sickle cell disease"],"prefix":"10.1111","volume":"91","author":[{"given":"Rabindra","family":"Paul","sequence":"first","affiliation":[{"name":"Howard University Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina P.","family":"Minniti","sequence":"additional","affiliation":[{"name":"Hematology Branch National Heart Lung and Blood Institute Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Nouraie","sequence":"additional","affiliation":[{"name":"Howard University Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Luchtman\u2010Jones","sequence":"additional","affiliation":[{"name":"Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Campbell","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohail","family":"Rana","sequence":"additional","affiliation":[{"name":"Howard University Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onyinye","family":"Onyekwere","sequence":"additional","affiliation":[{"name":"Howard University Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika S.","family":"Darbari","sequence":"additional","affiliation":[{"name":"Hematology Branch National Heart Lung and Blood Institute Bethesda MD USA"},{"name":"Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaid","family":"Ajayi","sequence":"additional","affiliation":[{"name":"Howard University Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Arteta","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Ensing","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Sable","sequence":"additional","affiliation":[{"name":"Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niti","family":"Dham","sequence":"additional","affiliation":[{"name":"Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Kato","sequence":"additional","affiliation":[{"name":"Hematology Branch National Heart Lung and Blood Institute Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark T.","family":"Gladwin","sequence":"additional","affiliation":[{"name":"Vascular Medicine Institute and Division of Pulmonary Allergy and Critical Care Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oswaldo L.","family":"Castro","sequence":"additional","affiliation":[{"name":"Howard University Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor R.","family":"Gordeuk","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21550"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.2.643.643"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198801000-00005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.44.6.459"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302303"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-005082"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.5.1787"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.91"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.70102"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.84"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31821ed2f0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13812"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90431-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.09.001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2002.120202"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-011072"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22900"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-010-9255-2"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.11.64"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.029165"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-3-2"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509143331104"},{"key":"e_1_2_6_25_1","first-page":"614","article-title":"Simultaneous occurrence of rib infarction and pulmonary infiltrates in sickle cell disease patients with acute chest syndrome","volume":"34","author":"Gelfand MJ","year":"1993","journal-title":"J Nucl Med"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.10.007"},{"key":"e_1_2_6_27_1","first-page":"105","article-title":"Acute chest syndrome in children with sickle cell disease. A retrospective analysis of 100 hospitalized cases","volume":"8","author":"Sprinkle RH","year":"1986","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.184028"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20791"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0730"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035477"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200710-1606OC"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23338"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1498OC"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.030767"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12051124"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80290-0"},{"key":"e_1_2_6_38_1","first-page":"20","article-title":"Respirator sequelae after acute hypoxemic respiratory failure in children with meningococcal septic shock","volume":"7","author":"Dahlem R","year":"2004","journal-title":"Crit Care Shock"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.10.44"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12118","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:09:13Z","timestamp":1700676553000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,3]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/ejh.12118"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12118","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,3]]}}}