{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:36:34Z","timestamp":1769499394498,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T00:00:00Z","timestamp":1369958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rare recurrent chromosomal translocation, t(14;19)(q32;q13), has been identified in a variety of B\u2010cell malignancies, including chronic lymphocytic leukemia (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>). We report a unique case of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> in a patient carrying both trisomy 12 and t(14;19) (q32;q13.1), in whom t(11;14)(q13;q32) developed at relapse. The patient was a 77\u2010yr\u2010old woman, and her lymphoma cells at presentation showed <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10<jats:sup>\u2212<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20<jats:sup>+<\/jats:sup>(dim), <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>23<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>38<jats:sup>+<\/jats:sup>, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c<jats:sup>+<\/jats:sup>. At relapse, the patient's lymphoma cells showed positive staining for cyclin D1 in addition to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>23. Lymphoma cells in specimens at both presentation and relapse were positive for lymphoid enhancer factor 1 (<jats:styled-content style=\"fixed-case\">LEF<\/jats:styled-content>1) and negative for sex\u2010determining region Y\u2010box 11 (<jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11). <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>1 <\/jats:italic><jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> became positive at relapse. Split <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> assay using <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>3<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">CCND<\/jats:styled-content>1<\/jats:italic> probes on lymph node specimens obtained at presentation and at autopsy confirmed that the translocation of <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>3<\/jats:italic> was solely detected in the lymph node at presentation and detected <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>3<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CCND<\/jats:styled-content>1<\/jats:italic> translocations in the specimen at autopsy. These observations indicated that <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>3<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CCND<\/jats:styled-content>1<\/jats:italic> had occurred in the same clone after treatment of the disease. In line with immunohistochemical and cytogenetic studies, additional <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> analysis of the <jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">JH<\/jats:styled-content> region showed the same sequence derived from <jats:styled-content style=\"fixed-case\">IGHV<\/jats:styled-content>4\u201034 in specimens obtained at disease onset and relapse.<\/jats:p>","DOI":"10.1111\/ejh.12119","type":"journal-article","created":{"date-parts":[[2013,4,13]],"date-time":"2013-04-13T13:06:45Z","timestamp":1365858405000},"page":"179-182","source":"Crossref","is-referenced-by-count":22,"title":["Acquisition of t(11;14) in a patient with chronic lymphocytic leukemia carrying both t(14;19)(q32;q13.1) and +12"],"prefix":"10.1111","volume":"91","author":[{"given":"Yuhki","family":"Nishida","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Kameda Medical Center Kamogawa\u2010shi, Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Kameda Medical Center Kamogawa\u2010shi, Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotaka","family":"Ugai","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Kameda Medical Center Kamogawa\u2010shi, Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Kameda Medical Center Kamogawa\u2010shi, Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Yamakura","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Kameda Medical Center Kamogawa\u2010shi, Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Kameda Medical Center Kamogawa\u2010shi, Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosei","family":"Matsue","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Kameda Medical Center Kamogawa\u2010shi, Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199601)15:1<38::AID-GCC6>3.0.CO;2-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199709)20:1<64::AID-GCC10>3.0.CO;2-F"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06416.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404695"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.102"},{"key":"e_1_2_6_7_1","first-page":"11","article-title":"Mantle cell lymphoma: from pathology and molecular pathogenesis to new therapeutic perspectives","volume":"91","author":"Salaverria I","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-189977"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.04.022"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.103"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-093401"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.9492"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1478.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25605"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1182\/blood.V93.4.1372","article-title":"Cytogenetic profile of lymphoma of follicle mantle lineage: correlation with clinicobiologic features","volume":"93","author":"Cuneo A","year":"1999","journal-title":"Blood"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12119","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:34:22Z","timestamp":1696289662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,31]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/ejh.12119"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12119","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,31]]}}}