{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:25:50Z","timestamp":1792599950699,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,7]],"date-time":"2013-07-07T00:00:00Z","timestamp":1373155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Decorin is a stromal\u2010produced small leucine\u2010rich proteoglycan known to attenuate tumour pro\u2010survival, migration, proliferation and angiogenic signalling pathways. Recent studies have shown that decorin interacts with the hepatocyte growth factor (HGF<\/jats:styled-content>) receptor c\u2010Met, a potential key pathway in multiple myeloma (MM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Decorin levels in paired peripheral blood and bone marrow plasma samples from healthy volunteers (HV<\/jats:styled-content>) (n<\/jats:italic>\u00a0=\u00a023), and patients with monoclonal gammopathy of undetermined significance (MGUS<\/jats:styled-content>) (n<\/jats:italic>\u00a0=\u00a041) and MM<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a019) were determined by ELISA<\/jats:styled-content>. Further, the ability of decorin to inhibit HGF<\/jats:styled-content>\u2010induced effects on MM<\/jats:styled-content> cell lines were analysed in vitro<\/jats:italic> using cell viability and Transwell migration assays.<\/jats:p><\/jats:sec>Results<\/jats:title>We found that decorin concentrations were significantly higher (P<\/jats:italic>\u00a0<\u00a00.05) in bone marrow (BM) plasma from HVs (median 35.2\u00a0ng\/mL; range, 15.3\u201399.1) compared with MGUS<\/jats:styled-content> (median 22.5\u00a0ng\/mL; range, 11.1\u201359.5) and patients with MM<\/jats:styled-content> (median 21.5\u00a0ng\/mL; range, 10.6\u201335.9). Decorin levels were higher in BM plasma than in peripheral blood in all groups, with a BM\/PB ratio of 3.9, 3.4 and 2.5 for HV<\/jats:styled-content>, MGUS<\/jats:styled-content> and MM<\/jats:styled-content>, respectively. A positive correlation (Spearman's \u03c1\u00a0=\u00a00.51, P<\/jats:italic>\u00a0<\u00a00.05) was found between simultaneously measured levels of HGF<\/jats:styled-content> and decorin in BM<\/jats:styled-content> plasma in HVs, but not in MGUS<\/jats:styled-content> or MM<\/jats:styled-content> samples. Functionally, decorin inhibited HGF<\/jats:styled-content>\u2010induced migration and viability of INA<\/jats:styled-content>\u20106 and ANBL<\/jats:styled-content>\u20106 MM<\/jats:styled-content> cell lines, independent of c\u2010Met down\u2010regulation.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our results show that decorin is down\u2010regulated in MGUS<\/jats:styled-content> and MM<\/jats:styled-content> bone marrow plasma and that it inhibits HGF<\/jats:styled-content>\u2010induced viability and migration of myeloma cell lines in vitro<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12125","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T09:35:11Z","timestamp":1366709711000},"page":"196-200","source":"Crossref","is-referenced-by-count":30,"title":["Decorin is down\u2010regulated in multiple myeloma and MGUS<\/scp> bone marrow plasma and inhibits HGF<\/scp>\u2010induced myeloma plasma cell viability and migration"],"prefix":"10.1111","volume":"91","author":[{"given":"Ida B.","family":"Kristensen","sequence":"first","affiliation":[{"name":"Institute of Clinical Research University of Southern Denmark Odense Denmark"},{"name":"Institute of Molecular Medicine University of Southern Denmark Odense Denmark"},{"name":"Department of Haematology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torstein B.","family":"R\u00f8","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine K.G. Jebsen Centre of Myeloma Research Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob H.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria B.","family":"Lyng","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars M.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Research University of Southern Denmark Odense Denmark"},{"name":"Department of Clinical Biochemistry and Pharmacology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik J.","family":"Ditzel","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine University of Southern Denmark Odense Denmark"},{"name":"Department of Oncology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magne","family":"B\u00f8rset","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine K.G. Jebsen Centre of Myeloma Research Norwegian University of Science and Technology Trondheim Norway"},{"name":"Department of Immunology and Transfusion Medicine St. Olavs University Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Abildgaard","sequence":"additional","affiliation":[{"name":"Institute of Clinical Research University of Southern Denmark Odense Denmark"},{"name":"Department of Haematology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.04.029"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23930"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091018"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-124164"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.11.009"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015233"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200901129"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0874"},{"key":"e_1_2_5_10_1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-034884"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr293"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25239"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.262766"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208329"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12125","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.12125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T20:31:14Z","timestamp":1692822674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,7]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/ejh.12125"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12125","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,7]]}}}