{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:08:25Z","timestamp":1780805305573,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Unexplained sudden death is common among patients with sickle cell diseases (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c prolongation is a risk factor for fatal arrhythmias among adults. This study sought to identify the predictors for <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c prolongation and determine whether <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c prolongation is associated with increased mortality in patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the electrocardiograms (<jats:styled-content style=\"fixed-case\">EKG<\/jats:styled-content>) and the transthoracic echocardiograms (<jats:styled-content style=\"fixed-case\">TTE<\/jats:styled-content>) of 140 consecutive adults (&gt;18\u00a0years) with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> from October 1996 to January of 2012. <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c prolongation was categorized into three gender\u2010specific categories based on previous publications. Stepwise regression was performed to evaluate <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval and mortality as dependent variables. Hemolytic burden as reflected in laboratory evaluation, diastolic, and systolic <jats:styled-content style=\"fixed-case\">TTE<\/jats:styled-content> variables were included in this model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a stepwise regression analysis, only increased tricuspid regurgitant jet velocity (<jats:styled-content style=\"fixed-case\">TRV<\/jats:styled-content>) (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.483, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015) had a significant association with <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval. Among 49 (35%) patients, the <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval was persistently prolonged (<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>) (&gt;450\u00a0ms in men, &gt;470\u00a0ms in women). Twenty\u2010one patients (15%) died over 9\u00a0years of follow\u2010up. <jats:styled-content style=\"fixed-case\">PP QT<\/jats:styled-content>c was associated with increased mortality (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>; 8.3 with 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.8\u201324.6, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) compared with normal <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c. In stepwise regression analysis, along with increased <jats:styled-content style=\"fixed-case\">TRV<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) and acute chest syndrome (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), prolonged <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) was independently associated with increased mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prolonged <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c among the patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> is an independent risk factor for increased mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12127","type":"journal-article","created":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T14:00:48Z","timestamp":1367071248000},"page":"170-178","source":"Crossref","is-referenced-by-count":29,"title":["Prolongation 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