{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T06:01:34Z","timestamp":1725602494596},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T00:00:00Z","timestamp":1369353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The occurrence of a thrombotic event in congenital bleeding disorders has drawn considerable attention in recent years. Both patients with hemophilia and patients with von <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>illebrand disease and even those with rare coagulation disorders have been shown to present occasional thrombotic events. Little is known on the comparative prevalence of arterial vs. venous thrombosis in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of the present investigation was to evaluate the prevalence of arterial vs. venous occlusions in hemophilia <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content> deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A time unlimited search of the literature was carried out using pertinent key words. Arterial or venous occlusions had to be proven by objective methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010five patients with hemophilia <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> have been reported to have had an arterial occlusion vs. six cases of <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content> deficiency. On the contrary, 34 patients with hemophilia <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> and 32 cases with <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content> deficiency have been reported to have presented with a venous thrombosis. The ratios of arterial vs. venous thrombosis are 3.72, 1.13, and 2.50 for hemophilia <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>, hemophilia <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, and hemophilia <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> combined, respectively, and 0.19 for <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content> deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hemophilia <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and hemophilia <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> do not protect from arterial occlusions (mainly acute coronary syndromes), whereas they assure some protection from venous thrombosis. The opposite seems true for <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content> deficiency. The potential significance of this discrepancy is discussed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12129","type":"journal-article","created":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T14:08:38Z","timestamp":1367071718000},"page":"152-156","source":"Crossref","is-referenced-by-count":9,"title":["Discrepant ratios of arterial vs. venous thrombosis in hemophilias <scp>A<\/scp> and <scp>B<\/scp> as compared to <scp>FVII<\/scp> deficiency"],"prefix":"10.1111","volume":"91","author":[{"given":"Antonio","family":"Girolami","sequence":"first","affiliation":[{"name":"Department of Medicine University of Padua, Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Berti de Marinis","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padua, Medical School Padua 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