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Clinical manifestations of haemophilia are spontaneous haemorrhage or acute bleeding caused by minor trauma, resulting in severe functional consequences that can culminate in a debilitating arthropathy. Life expectancy and quality of life of patients with haemophilia have dramatically improved over the last years, mainly for new therapeutic options and the awareness to the risk of\n                    <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    infections. Different clinical problems arise from this important change in history of patients with haemophilia. In particular, ageing\u2010related diseases, such as diabetes, hypertension and cancer, and chronic viral infections are emerging as new challenges in this patient population. Among the different types of chronic illnesses, renal diseases are of special interest as they involve some difficult management issues. In fact, decisions regarding adequate preventive strategies and viral infection treatment, the choice of the dialytic modality, placement of vascular access and prescription of dialytic treatments are particularly complicated, because only few data are available. In this review, we discuss the pathogenesis of renal damage in patients with haemophilia, especially in those with blood\u2010transmitted viral infections, and the major issues about the management of renal diseases, including problems related to dialytic treatment and kidney transplantation, providing practical algorithms to guide the clinical decision\u2010making process.\n                  <\/jats:p>","DOI":"10.1111\/ejh.12134","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T03:08:51Z","timestamp":1367982531000},"page":"287-294","source":"Crossref","is-referenced-by-count":28,"title":["Renal diseases in haemophilic patients: pathogenesis and clinical management"],"prefix":"10.1111","volume":"91","author":[{"given":"Pasquale","family":"Esposito","sequence":"first","affiliation":[{"name":"Unit of Nephrology Dialysis and Transplantation Fondazione IRCCS Policlinico S.Matteo and University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Rampino","sequence":"additional","affiliation":[{"name":"Unit of Nephrology Dialysis and Transplantation Fondazione IRCCS Policlinico S.Matteo and University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Gregorini","sequence":"additional","affiliation":[{"name":"Unit of Nephrology Dialysis and Transplantation Fondazione IRCCS Policlinico S.Matteo and University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Fasoli","sequence":"additional","affiliation":[{"name":"Unit of Nephrology Dialysis and Transplantation Fondazione IRCCS Policlinico S.Matteo and University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Gamba","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Haemophilia and Thrombosis Centre Fondazione IRCCS Policlinico S.Matteo and University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Dal","family":"Canton","sequence":"additional","affiliation":[{"name":"Unit of Nephrology Dialysis and Transplantation Fondazione IRCCS Policlinico S.Matteo and University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Hemophilia.The Merck Manuals: The Merck Manual for Healthcare Professionals.http:\/\/www.merckmanuals.com\/professional\/sec11\/ch136\/ch136c.html#sec11-ch136-ch136d-524. 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