{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:09:53Z","timestamp":1773245393354,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Large granular lymphocyte leukemias (<jats:styled-content style=\"fixed-case\">LGLL<\/jats:styled-content>s) represent a spectrum of biologically distinct lymphoproliferative diseases originating from either mature T cells (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3+) or natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>) cells (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3\u2212). Both T\u2010cell and <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\u2010cell <jats:styled-content style=\"fixed-case\">LGL<\/jats:styled-content> leukemia can manifest as indolent or aggressive neoplasia. These rare lymphoproliferative disorders are often associated with autoimmune diseases and impaired hematopoiesis. Symptomatic patients are treated with immunosuppressive drugs. The co\u2010association of T\u2010<jats:styled-content style=\"fixed-case\">LGLL<\/jats:styled-content> with clonal B\u2010cell disorders is reported in more than 10% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We describe the case of a 57\u2010yr\u2010old white male patient with no history of autoimmune disorders, with refractory T\u2010<jats:styled-content style=\"fixed-case\">LGLL<\/jats:styled-content> and myeloma who was treated with bortezomib and subsequently with lenalidomide. After 30\u00a0months of on\u2010going lenalidomide therapy, the patient is in partial remission from myeloma and in continuous complete hematological remission from T\u2010<jats:styled-content style=\"fixed-case\">LGLL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As far as we know, this is the first report of a patient with refractory T\u2010<jats:styled-content style=\"fixed-case\">LGLL<\/jats:styled-content> treated with bortezomib and lenalidomide. As refractory T\u2010<jats:styled-content style=\"fixed-case\">LGLL<\/jats:styled-content> is a challenging condition, we think that lenalidomide and bortezomib deserve further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12141","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T14:18:06Z","timestamp":1369059486000},"page":"183-186","source":"Crossref","is-referenced-by-count":8,"title":["Very long\u2010lasting remission of refractory T\u2010large granular lymphocytes leukemia and myeloma by lenalidomide treatment"],"prefix":"10.1111","volume":"91","author":[{"given":"Sabrina","family":"Pelliccia","sequence":"first","affiliation":[{"name":"Department of Hematology AO Sant'Andrea, La Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Di Napoli","sequence":"additional","affiliation":[{"name":"Department of Pathology AO Sant'Andrea, La Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Naso","sequence":"additional","affiliation":[{"name":"Department of Hematology AO Sant'Andrea, La Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Alma","sequence":"additional","affiliation":[{"name":"Department of Hematology AO Sant'Andrea, La Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Rebecchini","sequence":"additional","affiliation":[{"name":"Department of Hematology AO Sant'Andrea, La Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Hematology AO Sant'Andrea, La Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-3-263"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-403873"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.018481"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.06.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403617"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190801932635"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPIIL1Y5QXTIBP"},{"key":"e_1_2_8_9_1","first-page":"956","article-title":"A case of concomitant T\u2010cell large granular lymphocyte leukemia and plasma cell myeloma","volume":"9","author":"Nawaz U","year":"2011","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb06414.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP1T0JPBLSLAQF"},{"key":"e_1_2_8_12_1","first-page":"798","article-title":"CD20dim\u2010positive T\u2010cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma","volume":"3","author":"Xu X","year":"2010","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806447105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0614-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12053"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200454"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/513702"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201006\u2010435297"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12141","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:34:20Z","timestamp":1696289660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,28]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/ejh.12141"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12141","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,28]]}}}