{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:41:32Z","timestamp":1769575292064,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We retrospectively compared the antileukemic effects of chemotherapy alone and chemotherapy followed by modified donor lymphocyte infusion (<jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>) in 82 patients with relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) without <jats:italic>in vitro <\/jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell depletion. We also investigated prognostic factors in patients receiving chemotherapy followed by modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>. Thirty\u2010two patients received chemotherapy alone, and the remaining 50 patients received chemotherapy followed by modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>. In patients receiving chemotherapy followed by modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>, complete remission rate was significantly higher (64.0% vs. 12.5%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.000), the incidence of relapse was significantly lower (50.0% vs. 100.0%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000), and disease\u2010free survival was significantly improved (36.0% vs. 0.0%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.000) compared with patients receiving chemotherapy alone. Multivariate analysis demonstrated that patients with chronic graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>) after intervention (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.000) and patients receiving chemotherapy followed by modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content> (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.037) were associated with a lower relapse rate. Furthermore, in patients receiving chemotherapy followed by modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>, multivariate analysis demonstrated that chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> after modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content> (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.039) and duration of minimal residual disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) (\u2212) \u22654\u00a0months after modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content> (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.001) were associated with a lower relapse rate. Our study is the first to suggest that chemotherapy followed by modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content> is associated with stronger antileukemic effects and better survival in relapsed acute leukemia after haploidentical <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> without <jats:italic>in vitro <\/jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell depletion. Furthermore, our study suggests that lack of chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> and duration of <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> (\u2212) &lt;4\u00a0months after modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content> are associated with higher relapse rates in patients receiving chemotherapy followed by modified <jats:styled-content style=\"fixed-case\">DLI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ejh.12168","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T09:46:37Z","timestamp":1373449597000},"page":"304-314","source":"Crossref","is-referenced-by-count":55,"title":["Chemotherapy followed by modified donor lymphocyte infusion as a treatment for relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation without <i>in vitro <\/i><scp>T<\/scp>\u2010cell depletion: superior outcomes compared with chemotherapy alone and an analysis of prognostic factors"],"prefix":"10.1111","volume":"91","author":[{"given":"Chen\u2010Hua","family":"Yan","sequence":"first","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai\u2010Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 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