{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:30:01Z","timestamp":1776101401105,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Multicentric Castleman disease (<jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>) is a distinct lymphoproliferative disorder characterized by inflammatory symptoms, lymphadenopathy, splenomegaly, and cytopenia. Kaposi's sarcoma\u2010associated herpesvirus (<jats:styled-content style=\"fixed-case\">KSHV<\/jats:styled-content>), also called human herpesvirus\u20108 (<jats:styled-content style=\"fixed-case\">HHV\u20108<\/jats:styled-content>), is the cause of virtually all cases of <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> occurring in patients with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection. <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> lesions characteristically contain <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108\u2010infected polyclonal IgM\u03bb plasmablasts. A high frequency of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108\u2010related non\u2010Hodgkin lymphoma has been reported in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We now report on three patients who presented with severe symptoms of <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>, extreme splenomegaly, and rapid expansion of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphocytosis (44\u201381%) attributable to circulating <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108 positive plasmablasts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The circulating plasmablastic cells shared the phenotype (IgM\u03bb, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19+, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20\u2212 <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>138\u2212) of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108\u2010infected cells from <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> lesions, mimicking the leukemic phase of large B\u2010cell lymphoma occurring in <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108\u2010related <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>. These patients displayed a very high <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108 viral load in blood (&gt;7 logs <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108 <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> copies\/ml) and high levels of serum <jats:styled-content style=\"fixed-case\">vIL<\/jats:styled-content>\u20106, the viral homolog of human interleukin 6. Serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 were also abnormally elevated. <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108\u2010infected cells were demonstrated by immunoglobulin gene rearrangement analysis, to be polyclonal and likely represent an expansion of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108\u2010infected cells similar to those found in <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thus, the spectrum of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108\u2010related plasmablastic lymphoproliferative disorders in patients with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection is expanded to include <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108+ polyclonal IgM\u03bb <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphocytosis. At onset, this lymphoproliferative disorder may mimic plasmablastic leukemia\/lymphoma. Recognizing this unusual complication may have important implications in treatment decision avoiding unnecessary toxicity to the patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12191","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T05:44:43Z","timestamp":1378100683000},"page":"497-503","source":"Crossref","is-referenced-by-count":19,"title":["Human herpesvirus 8+ polyclonal <scp>I<\/scp>g<scp>M<\/scp>\u03bb <scp>B<\/scp>\u2010cell lymphocytosis mimicking plasmablastic leukemia\/lymphoma in <scp>HIV<\/scp>\u2010infected patients"],"prefix":"10.1111","volume":"91","author":[{"given":"Eric","family":"Oksenhendler","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology H\u00f4pital Saint\u2010Louis Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"},{"name":"Univ Paris Diderot Sorbonne Paris Cit\u00e9 Paris 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