{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T05:26:26Z","timestamp":1767245186241},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,9]],"date-time":"2013-11-09T00:00:00Z","timestamp":1383955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the impact of graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>) and prognostic factors for patients with myelodysplastic syndrome (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>) after allogeneic hematopoietic cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>), we retrospectively reviewed 115 patients with <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> or acute myeloid leukemia with multilineage dysplasia (<jats:styled-content style=\"fixed-case\">AML\u2010MLD<\/jats:styled-content>) after allo\u2010<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> at our center. Eighty one patients received reduced\u2010intensity conditioning (<jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content>) regimens, whereas 34 received myeloablative conditioning regimens. Although the <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> group was significantly older and included more patients with poor cytogenetic risk, no difference in 4\u2010yr overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was seen between the two groups. In a multivariate analysis, covariates associated with a worse <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> were the French\u2010American\u2010British stage of refractory anemia excess blasts in transformation\/<jats:styled-content style=\"fixed-case\">AML\u2010MLD<\/jats:styled-content> at peak, poor cytogenetic risk, bone marrow blasts of 20% or higher at <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> and the absence of chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">cGVHD<\/jats:styled-content>). By using semi\u2010landmark analyses, we found that the presence of <jats:styled-content style=\"fixed-case\">cGVHD<\/jats:styled-content> significantly improved <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in high\u2010risk patients or the <jats:styled-content style=\"fixed-case\">RIC<\/jats:styled-content> group. However, there was no difference in <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> between those with and without <jats:styled-content style=\"fixed-case\">cGVHD<\/jats:styled-content> among low\u2010risk MDS patients. These findings suggest that the graft\u2010versus\u2010leukemia effect may be more beneficial in high\u2010risk patients who do not receive intensive preparative regimens.<\/jats:p>","DOI":"10.1111\/ejh.12214","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T15:50:55Z","timestamp":1381852255000},"page":"137-146","source":"Crossref","is-referenced-by-count":17,"title":["Positive impact of chronic graft\u2010versus\u2010host disease on the outcome of patients with <i>de novo<\/i> myelodysplastic syndrome after allogeneic hematopoietic cell transplantation: a single\u2010center analysis of 115 patients"],"prefix":"10.1111","volume":"92","author":[{"given":"Nobuhiro","family":"Hiramoto","sequence":"first","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation Division National Cancer Center Hospital Tokyo 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