{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:22:40Z","timestamp":1780363360278,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Transfused patients with sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>) are at risk of iron overload and identifying such patients is important to prevent associated complications. Our aim was to assess the efficacy of serial serum ferritin (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>) measurements in identifying patients with hepatic iron overload as assessed by liver <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and its usefulness in guiding decision making regarding chelation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>We retrospectively compared the results of 49 liver <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scans (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>) with the median serum ferritin (<jats:styled-content style=\"fixed-case\">MSF<\/jats:styled-content>) values for 28 patients in our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a nonlinear increment of <jats:styled-content style=\"fixed-case\">MSF<\/jats:styled-content> with increasing liver iron concentration (<jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>). 18.4% and 47.4% of abnormal <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>s corresponded to <jats:styled-content style=\"fixed-case\">MSF<\/jats:styled-content> &lt;1000\u00a0mcg\/L and &lt;2000\u00a0mcg\/L, respectively. 30.4% of patients with <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content> of 7\u00a0mg\/g dry weight or higher had a <jats:styled-content style=\"fixed-case\">MSF<\/jats:styled-content> &lt;2000\u00a0mcg\/L. In 38.5% of patients receiving chelation, <jats:styled-content style=\"fixed-case\">MSF<\/jats:styled-content> offered little information regarding the efficacy of treatment and was sometimes misleading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serial serum ferritin measurements in adult transfused patients with sickle cell disease have a low sensitivity for identifying patients with iron overload and are of limited value in guiding decision making regarding initiation or monitoring of chelation therapy. The iron status of such high risk patients should be assessed by more definitive ways such as <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12230","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T07:52:36Z","timestamp":1383292356000},"page":"164-167","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of serial serum ferritin measurements and liver iron concentration assessed by <scp>MRI<\/scp> in adult transfused patients with sickle cell disease"],"prefix":"10.1111","volume":"92","author":[{"given":"Dimitris A.","family":"Tsitsikas","sequence":"first","affiliation":[{"name":"Department of Haematology Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Nzouakou","sequence":"additional","affiliation":[{"name":"Department of Haematology Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venus","family":"Ameen","sequence":"additional","affiliation":[{"name":"Department of Haematology Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala","family":"Sirigireddy","sequence":"additional","affiliation":[{"name":"Department of Haematology Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Amos","sequence":"additional","affiliation":[{"name":"Department of Haematology Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1824"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12413"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24330"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.014696"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02527.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.3.253"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.443"},{"key":"e_1_2_7_9_1","volume-title":"Division of Blood Diseases and Resources NHLBI The Management of Sickle Cell Disease","year":"2002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-203323"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02298.x"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12230","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:21:32Z","timestamp":1695511292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,26]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/ejh.12230"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12230","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,26]]}}}