{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:09:18Z","timestamp":1768010958919,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to evaluate the therapeutic potential of bevacizumab with or without systemic chemotherapy for adult <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell leukemia\/lymphoma (<jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>) and clarify the significance of angiogenesis for <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NOD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>hi\u2010<jats:italic>scid<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20102<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u03b3<jats:sup>null<\/jats:sup> (<jats:styled-content style=\"fixed-case\">NOG<\/jats:styled-content>) mice were used as recipients of tumor cells from a patient with <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>, which engraft and proliferate in a microenvironment\u2010dependent manner. The <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> cells could be serially transplanted in <jats:styled-content style=\"fixed-case\">NOG<\/jats:styled-content> mice, but could not be maintained in <jats:italic>in vitro<\/jats:italic> cultures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Injection of bevacizumab alone significantly increased necrosis and decreased vascularization in the tumor tissue. Levels of human soluble interleukin two receptor in the serum (reflecting the <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> tumor burden) of bevacizumab\u2010treated mice were significantly lower than in untreated mice. Although bevacizumab monotherapy showed these clear anti\u2010angiogenesis effects, it did not prolong survival. In contrast, injection of bevacizumab together with cyclophosphamide, doxorubicin, vincristine, prednisolone (<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content>) led to a significant prolongation of survival of the <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> mice relative to <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first report to evaluate the efficacy of bevacizumab for <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> in a tumor microenvironment\u2010dependent model. Bevacizumab therapy combined with chemotherapy could be a valuable treatment strategy for that subgroup of <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> probably depending to a large extent on angiogenesis via vascular endothelial growth factor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12231","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T12:46:01Z","timestamp":1383655561000},"page":"219-228","source":"Crossref","is-referenced-by-count":7,"title":["Antitumor effects of bevacizumab in a microenvironment\u2010dependent human adult <scp>T<\/scp>\u2010cell leukemia\/lymphoma mouse model"],"prefix":"10.1111","volume":"92","author":[{"given":"Fumiko","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asahi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomiko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Takino","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Ri","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kusumoto","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakatsu","family":"Hishizawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Imada","sequence":"additional","affiliation":[{"name":"Department of Hematology Kokura Memorial Hospital Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Takaori\u2010Kondo","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Niimi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuzo","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Tumor Immunology Aichi Medical University School of Medicine Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0941-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2111"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08051.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-414490"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702731"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10144"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104390"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61904-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.7849"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032691"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103799"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061884"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021491"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3055"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2390"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.9.3383"},{"key":"e_1_2_9_19_1","first-page":"2719","article-title":"Vascular endothelial growth factor and cellular chemotaxis: a possible autocrine pathway in adult T\u2010cell leukemia cell invasion","volume":"7","author":"Hayashibara T","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02166-09"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-75647-7_3"},{"key":"e_1_2_9_22_1","first-page":"36","article-title":"Image Processing with ImageJ","volume":"11","author":"Abramoff MD","year":"2004","journal-title":"Biophotonics Int"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1996.tb02116.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02371.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2012.12"},{"key":"e_1_2_9_26_1","first-page":"4950","article-title":"The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP\u2010resistant human diffuse large cell lymphoma xenograft model","volume":"6","author":"Mohammad RM","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1988.tb00028.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900699"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202692"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0226"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb03224.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1175"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2403"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3455"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104819"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909530"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.6116"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.2762"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.3472"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.10.73"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-013-0332-6"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12231","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:28:13Z","timestamp":1695540493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,26]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/ejh.12231"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12231","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,26]]}}}