{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:01:25Z","timestamp":1761102085264},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study's objective was to assess the cost\u2010effectiveness of preoperative transfusion compared with no preoperative transfusion in patients with sickle cell disease undergoing low\u2010 or medium\u2010risk surgery. Seventy patients with sickle cell disease (Hb<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\/S\u00df<jats:sup>0<\/jats:sup>thal genotypes) undergoing elective surgery participated in a multicentre randomised trial, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ransfusion <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lternatives <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>reoperatively in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ickle <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ell <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease (<jats:styled-content style=\"fixed-case\">TAPS<\/jats:styled-content>). Here, a cost\u2010effectiveness analysis based on evidence from that trial is presented. A decision\u2010analytic model is used to incorporate long\u2010term consequences of transfusions and acute chest syndrome. Costs and health benefits, expressed as quality\u2010adjusted life years (<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s), are reported from the \u2018within\u2010trial\u2019 analysis and for the decision\u2010analytic model. The probability of cost\u2010effectiveness for each form of management is calculated taking into account the small sample size and other sources of uncertainty. In the range of scenarios considered in the analysis, preoperative transfusion was more effective, with the mean improvement in <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s ranging from 0.018 to 0.206 per patient, and also less costly in all but one scenario, with the mean cost difference ranging from \u2212\u00a3813 to \u00a326. All scenarios suggested preoperative transfusion had a probability of cost\u2010effectiveness &gt;0.79 at a cost\u2010effectiveness threshold of \u00a320\u00a0000 per <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ejh.12232","type":"journal-article","created":{"date-parts":[[2013,11,9]],"date-time":"2013-11-09T12:12:53Z","timestamp":1383999173000},"page":"249-255","source":"Crossref","is-referenced-by-count":9,"title":["Cost\u2010effectiveness analysis of preoperative transfusion in patients with sickle cell disease using evidence from the <scp>TAPS<\/scp> trial"],"prefix":"10.1111","volume":"92","author":[{"given":"Eldon","family":"Spackman","sequence":"first","affiliation":[{"name":"Centre for Health Economics University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Sculpher","sequence":"additional","affiliation":[{"name":"Centre for Health Economics University of York York UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Haematology Guy's and St Thomas' Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moira","family":"Malfroy","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Llewelyn","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Choo","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Hodge","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant London 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