{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:16:09Z","timestamp":1791353769929,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T00:00:00Z","timestamp":1387324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>One third of CML patients treated with first line imatinib have suboptimal responses or treatment failures with increased risk for disease progression. Imatinib is actively transported into cells by the SLC22A1 transporter (<jats:styled-content style=\"fixed-case\">hOCT<\/jats:styled-content>1) and its genetic variants may affect intracellular drug import. We studied the effect of SLC22A1 genetic variants on long\u2010term outcomes of imatinib treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 167 patients, 94% in chronic phase, were analyzed for rs41267797, rs683369, rs12208357, and rs628031 variants using the Sequenom Mass<jats:styled-content style=\"fixed-case\">ARRAY<\/jats:styled-content> platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rates of CHR, MCyR, CCyR, and MMolR were not significantly different according to allelic variants. However, patients with AA or GA rs628031 genotypes had a higher incidence of poor response to imatinib compared to the GG genotype (47% compared to 29%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06), and a higher rate of KD mutation discovery (8\/16 vs. 5\/27, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), suggesting that secondary resistance was more common in these genotypes. Median EFS was shorter for rs628031 genotype AA\/AG compared with the GG genotype (61\u00a0months and not reached, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05), and 5\u00a0yr OS rates were lower for patients with the rs628031 genotypes AA\/AG compared with the GG genotype (88% and 97%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). Patients with AA\/GA rs628031 and additional rare genotypes had worse EFS and OS compared to patients with only AA\/GA rs628031 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02 for EFS and 0.01 for OS). There was no difference in pretreatment SLC22A1 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression levels in patients with rs628031 genotypes GG\/AA or GA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Studying <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>22A1 genetic variants prior to <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> initiation could influence treatment decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12235","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T19:17:31Z","timestamp":1384197451000},"page":"283-288","source":"Crossref","is-referenced-by-count":34,"title":["<scp>OCT<\/scp>1 genetic variants are associated with long term outcomes in imatinib treated chronic myeloid leukemia patients"],"prefix":"10.1111","volume":"92","author":[{"given":"Maya","family":"Koren\u2010Michowitz","sequence":"first","affiliation":[{"name":"Division of Hematology Chaim Sheba Medical Center Tel Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehavit","family":"Buzaglo","sequence":"additional","affiliation":[{"name":"Division of Hematology Chaim Sheba Medical Center Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ribakovsky","sequence":"additional","affiliation":[{"name":"Division of Hematology Chaim Sheba Medical Center Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Campus Virchow Klinikum Charit\u00e9 Berlin 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