{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:11:47Z","timestamp":1790795507448,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Abstract<\/jats:title>T\u2010cell antigens [CD<\/jats:styled-content>5,CD<\/jats:styled-content>1a,CD<\/jats:styled-content>8] define early T\u2010cell precursor acute lymphoblastic leukemia (ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content>). To understand immature T\u2010ALL<\/jats:styled-content> of which ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content> is part, we used these antigens to subcategorize non\u2010ETP<\/jats:styled-content> T\u2010ALL<\/jats:styled-content> for examining expression of myeloid\/stem cell antigens (M\/S) and clinical features. Using CD<\/jats:styled-content>5 (+\/\u2212) to start categorization, we studied 69 routinely immunophenotyped patients with T\u2010ALL<\/jats:styled-content>. CD<\/jats:styled-content>5\u2212<\/jats:sup> was a homogenous (CD<\/jats:styled-content>8,CD<\/jats:styled-content>1a)\u2212<\/jats:sup> M\/S+<\/jats:sup> ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content> group (n\u00a0<\/jats:italic>=\u00a09). CD<\/jats:styled-content>5+<\/jats:sup> cases were (CD<\/jats:styled-content>8,CD<\/jats:styled-content>1a)\u2212<\/jats:sup> pre\u2010T\u2010ALL<\/jats:styled-content> (n\u00a0<\/jats:italic>=\u00a022) or (CD<\/jats:styled-content>8,CD<\/jats:styled-content>1a)+<\/jats:sup> (n\u00a0<\/jats:italic>=\u00a038) thymic\/cortical T\u2010ALL<\/jats:styled-content>; M\/S+<\/jats:sup> 20\/22 (90.91%) in former and 22\/38 (57.89%) in latter (P\u00a0<\/jats:italic>=\u00a00.007). ETP<\/jats:styled-content>\u2010 and pre\u2010T\u2010ALL<\/jats:styled-content> together (CD<\/jats:styled-content>1a\u2212<\/jats:sup>,CD<\/jats:styled-content>5\u2212\/+<\/jats:sup> immature T\u2010ALL<\/jats:styled-content> group) were nearly always M\/S+<\/jats:sup> (29\/31; 93.55%). In multivariate analysis, only ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content> predicted poor overall survival (P<\/jats:italic>\u00a0=\u00a00.02). We conclude (i) CD<\/jats:styled-content>5 negativity in T\u2010ALL<\/jats:styled-content> almost always means ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content>. CD<\/jats:styled-content>1a and CD<\/jats:styled-content>8 negativity, as much as CD<\/jats:styled-content>5, marks immaturity in T\u2010ALL<\/jats:styled-content>, and the CD<\/jats:styled-content>5+\/\u2212<\/jats:sup>\/CD<\/jats:styled-content>1a\u2212<\/jats:sup>\/CD<\/jats:styled-content>8\u2212<\/jats:sup> immature T\u2010ALL<\/jats:styled-content> group needs further study to understand the biology of the T\u2010ALL<\/jats:styled-content>\u2013myeloid interface. (ii) ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content> patients may be pre\u2010T\u2010ALL<\/jats:styled-content> if CD<\/jats:styled-content>2+<\/jats:sup>; CD<\/jats:styled-content>2+<\/jats:sup>, conversely, CD<\/jats:styled-content>5\u2212<\/jats:sup>\/CD<\/jats:styled-content>1a\u2212<\/jats:sup>\/CD<\/jats:styled-content>8\u2212<\/jats:sup> pre\u2010T ALL<\/jats:styled-content> patients are ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content>. (iii) Immunophenotypic workup of T\u2010ALL<\/jats:styled-content> must not omit CD<\/jats:styled-content>1a, CD<\/jats:styled-content>5, CD<\/jats:styled-content>8 and CD<\/jats:styled-content>2, and positivity of antigens should preferably be defined as recommended for ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content>, so that this entity can be better evaluated in future studies of immature T\u2010ALL<\/jats:styled-content>, a group to which ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content> belongs. (iv) ETP<\/jats:styled-content>\u2010ALL<\/jats:styled-content> has poor prognosis.<\/jats:p>","DOI":"10.1111\/ejh.12238","type":"journal-article","created":{"date-parts":[[2013,12,14]],"date-time":"2013-12-14T15:17:55Z","timestamp":1387034275000},"page":"211-218","source":"Crossref","is-referenced-by-count":34,"title":["Immunophenotypic analysis of T\u2010acute lymphoblastic leukemia. A CD<\/scp>5\u2010based ETP<\/scp>\u2010ALL<\/scp> perspective of non\u2010ETP<\/scp> T\u2010ALL<\/scp>"],"prefix":"10.1111","volume":"92","author":[{"given":"Anita","family":"Chopra","sequence":"first","affiliation":[{"name":"Department of Laboratory Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Bakhshi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman Kumar","family":"Pramanik","sequence":"additional","affiliation":[{"name":"Command Hospital (Eastern Command) Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra Mohan","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Biostatatistics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smeeta","family":"Gajendra","sequence":"additional","affiliation":[{"name":"Department of Laboratory Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gogia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagan","family":"Chandramohan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachna","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajive","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Oncology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052603"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.116"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20684"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70314-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10725"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08955.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2011.49"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-012-0224-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112239"},{"key":"e_1_2_8_11_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. 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