{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:21:15Z","timestamp":1790266875149,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T00:00:00Z","timestamp":1394150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Approximately 30% of DLBCL<\/jats:styled-content> patients are older than 70\u00a0yr. This study evaluated the prognostic impact of a cachexia score (CS<\/jats:styled-content>) including fat tissue loss (adipopenia) and sarcopenia as assessed by computed tomography (CT<\/jats:styled-content> scan) in elderly DLBCL<\/jats:styled-content> patients treated with chemotherapy and rituximab (R<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This retrospective analysis included 80 DLBCL<\/jats:styled-content> patients older than 70\u00a0yr treated with R<\/jats:styled-content>\u2010CHOP<\/jats:styled-content> or R<\/jats:styled-content>\u2010miniCHOP<\/jats:styled-content>. Skeletal muscle (SM<\/jats:styled-content>) and visceral (V<\/jats:styled-content>) and subcutaneous (S<\/jats:styled-content>) adipose (A<\/jats:styled-content>) tissues were measured by analysing CT<\/jats:styled-content> images at the third lumbar (L<\/jats:styled-content>3) level.<\/jats:p><\/jats:sec>Results<\/jats:title>The median age of the patients was 78\u00a0yr. Forty\u2010four and 46 patients were considered sarcopenic and adipopenic, respectively. The median progression\u2010free survival (PFS<\/jats:styled-content>) was 13.6\u00a0months in the adipopenic group and 49.4\u00a0months in the non\u2010adipopenic group [hazard ratio (HR<\/jats:styled-content>)\u00a0=\u00a02.27; 95% confidence interval (CI<\/jats:styled-content>): 1.3\u20134; P<\/jats:italic>\u00a0=\u00a00.0042]. The median overall survival (OS<\/jats:styled-content>) was 25.7\u00a0months in the adipopenic group and 57.1\u00a0months in the non\u2010adipopenic group (HR<\/jats:styled-content>\u00a0=\u00a01.93; 95% CI<\/jats:styled-content>: 1.05\u20133.55; P<\/jats:italic>\u00a0=\u00a00.0342). A two\u2010point CS<\/jats:styled-content> including adipopenia and sarcopenia was created and defined two distinct risk groups with differences in outcomes that were highly significant. The CS<\/jats:styled-content> was predictive of the prognosis in a multivariate analysis including body mass index (BMI<\/jats:styled-content>) (< or \u226525\u00a0kg\/m2<\/jats:sup>), age (< or \u226580\u00a0yr), international prognostic index (IPI<\/jats:styled-content>) and albuminaemia (HR<\/jats:styled-content>\u00a0=\u00a03.67; 95% CI<\/jats:styled-content>\u00a0=\u00a01.93\u20136.97; P<\/jats:italic>\u00a0<\u00a00.0001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A CS<\/jats:styled-content> including sarcopenia and adipopenia, assessed by a single CT<\/jats:styled-content> scan slice, predicts outcome independent of BMI<\/jats:styled-content> and the IPI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12285","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T17:06:56Z","timestamp":1392224816000},"page":"9-18","source":"Crossref","is-referenced-by-count":120,"title":["Prognostic impact of fat tissue loss and cachexia assessed by computed tomography scan in elderly patients with diffuse large B<\/scp>\u2010cell lymphoma treated with immunochemotherapy"],"prefix":"10.1111","volume":"93","author":[{"given":"Vincent","family":"Camus","sequence":"first","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"},{"name":"Centre Henri Becquerel INSERM U918, IRIB Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Lanic","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"},{"name":"Centre Henri Becquerel INSERM U918, IRIB Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer\u00f4me","family":"Kraut","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Modzelewski","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Henri Becquerel Rouen France"},{"name":"Faculty of Medicine QuantIF\u2010LITIS UPRES EA 4108 University of Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Clatot","sequence":"additional","affiliation":[{"name":"Centre Henri Becquerel INSERM U918, IRIB Rouen France"},{"name":"Department of Oncology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean M.","family":"Picquenot","sequence":"additional","affiliation":[{"name":"Centre Henri Becquerel INSERM U918, IRIB Rouen France"},{"name":"Department of Pathology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Contentin","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Lenain","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luminata","family":"Groza","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Lemasle","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Fronville","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Cardinael","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure","family":"Fontoura","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Chamseddine","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Brehar","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aspasia","family":"Stamatoullas","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"},{"name":"Centre Henri Becquerel INSERM U918, IRIB Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Lepr\u00eatre","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"},{"name":"Centre Henri Becquerel INSERM U918, IRIB Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Tilly","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"},{"name":"Centre Henri Becquerel INSERM U918, IRIB Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Jardin","sequence":"additional","affiliation":[{"name":"Department of Haematology Centre Henri Becquerel Rouen France"},{"name":"Centre Henri Becquerel INSERM U918, IRIB Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058211"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr411"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70069-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.050617"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388470"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0973-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.6674"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.7442"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(05)80001-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1345"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0505-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601620"},{"key":"e_1_2_7_15_1","first-page":"1","article-title":"Sarcopenia is an independent prognostic factor in elderly patients with diffuse large B\u2010cell lymphoma treated with immunochemotherapy","author":"Lanic H","year":"2013","journal-title":"Leuk Lymphoma"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.09.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.09.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4585"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-003-0025-y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1139\/H08-075"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e328331124a"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00744.2004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.5-3-224"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.06.003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/39.4.631"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2006.tb00183.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.2100"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27819"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-380949"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.11.006"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm563"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12285","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:21:27Z","timestamp":1695514887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/ejh.12285"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12285","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,7]]}}}