{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:50:59Z","timestamp":1791355859012,"version":"4.3.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Hypogammaglobulinemia, commonly encountered in chronic lymphocytic leukemia (CLL<\/jats:styled-content>), is one of the main causes of morbidity and mortality; however, its prognostic significance in patients diagnosed in early stages of disease remains uncertain. The aim of this study was to evaluate the predictive power of hypogammaglobulinemia at Bonet stage A.<\/jats:p><\/jats:sec>Methods<\/jats:title>Using the database of the Israeli CLL<\/jats:styled-content> Study Group, we analyzed the relationship between low serum levels of IgG, IgA, and IgM; the presence of paraproteinemia, as well as other well\u2010recognized prognostic markers in CLL<\/jats:styled-content>; and time to first treatment (TTT<\/jats:styled-content>) and overall survival. A total of 1113 patients consecutively diagnosed during the last 25\u00a0yrs with Binet stage A CLL<\/jats:styled-content> were evaluated, and baseline information on serum immunoglobulin levels was found in 857 of the cases.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall survival times correlated with age >65\u00a0yr, male gender, the presence of lymphadenopathy, high serum beta 2\u2010microglobulin (b2m), CD<\/jats:styled-content>38 and ZAP<\/jats:styled-content>\u201070 expression, but not with low levels of immunoglobulin or the presence of paraproteinemia. By univariate analysis, patients with low IgA levels had a shorter TTT<\/jats:styled-content>; however, on multivariate analysis, the presence of lymphadenopathy (P<\/jats:italic> 0.02), b2m (P<\/jats:italic> 0.04), CD<\/jats:styled-content>38 (P<\/jats:italic>\u00a0<\u00a00.001), and ZAP<\/jats:styled-content>\u201070 (P<\/jats:italic>\u00a0<\u00a00.001) was the only laboratory parameters with prognostic significance.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In our cohort of patients with early\u2010stage CLL<\/jats:styled-content>, baseline hypogammaglobulinemia and the presence of paraproteinemia were not found to correlate with prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12290","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T21:56:41Z","timestamp":1392760601000},"page":"29-33","source":"Crossref","is-referenced-by-count":25,"title":["Serum immunoglobulin levels at diagnosis have no prognostic significance in stage A chronic lymphocytic leukemia: a study of 1113 cases from the Israeli CLL<\/scp> Study Group"],"prefix":"10.1111","volume":"93","author":[{"given":"Lev","family":"Shvidel","sequence":"first","affiliation":[{"name":"Kaplan Medical Center Rehovot Hadassah and Hebrew University Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Tadmor","sequence":"additional","affiliation":[{"name":"Bnai Zion Medical Center Haifa Technion Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Braester","sequence":"additional","affiliation":[{"name":"Western Galilee Hospital Nahariya Bar Ilan University Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osnat","family":"Bairey","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Petah\u2010Tikva Tel Aviv Medical University Petah\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Rahimi\u2010Levene","sequence":"additional","affiliation":[{"name":"Assaf Harofeh Medical Center Zerifin Tel Aviv Medical University Tzrifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Herishanu","sequence":"additional","affiliation":[{"name":"Sourasky Medical Center Tel Aviv Tel Aviv Medical University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Klepfish","sequence":"additional","affiliation":[{"name":"Wolfson Medical Center Holon Tel Aviv Medical University Holon Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Ruchlemer","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center Jerusalem Ben Gurion University Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Berrebi","sequence":"additional","affiliation":[{"name":"Kaplan Medical Center Rehovot Hadassah and Hebrew University Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Polliack","sequence":"additional","affiliation":[{"name":"Hadassah University Hospital and Hebrew University Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Israeli CLL Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V46.2.219.219"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1182\/asheducation.V2012.1.76.3806845","article-title":"Implications of new prognostic markers in chronic lymphocytic leukemia","volume":"2012","author":"Chiorazzi N","year":"2012","journal-title":"Hematology Am Soc Hematol Educ 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